2. Metabolic Enzyme/Protease Others
  3. Reference Standards Endogenous Metabolite
  4. AY 9944 (Standard)

AY 9944 (Standard) 是 AY 9944 (HY-107420) 的分析标准品。本产品用于研究及分析应用。AY 9944 是一种特异的胆固醇生物合成 (cholesterol biosynthesis) 抑制剂。AY 9944 抑制 7- 脱氢胆固醇 Δ7- 还原酶 (DHCR7) 酶，其 IC50 值为 13 nM。AY 9944 引起胆固醇不足和 7DHC 积累。在高剂量下，AY 9944 也可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，这会导致胆固醇 8-en-3β-ol 的积累。

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AY 9944 (Standard)

AY 9944 (Standard) Chemical Structure

CAS No. : 366-93-8

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AY 9944 (Standard) 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

AY 9944 (Standard) is the analytical standard of AY 9944 (HY-107420). This product is intended for research and analytical applications. AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3].

IC50 & Target

IC50: 13 nM (DHCR7)1
分子量

464.30

Formula

C22H30Cl4N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AY 9944 (Standard) 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AY 9944 (Standard)366-93-8Reference StandardsEndogenous Metabolitecholesterolreductasebiosynthesis7DHCaccumulationΔ7-Δ8isomerasehypocholesterolemiaInhibitorinhibitorinhibit

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目录号：
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