2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Bicyclo-GABA

Bicyclo-GABA 是一种选择性 甜菜碱/GABA 转运体 1 (BGT1) 竞争性非转运抑制剂，其 IC50 为 590 nM。Bicyclo-GABA 在 α1β2γ2 GABAA 受体上表现出低微摩尔水平的激动活性，其 EC50 为 5.1 μM。Bicyclo-GABA 对 BGT1 的活性比 GAT3 高 129 倍。Bicyclo-GABA 作为一种有价值的工具化合物，有助于阐明其在中枢和外周神经系统中的药理学作用。

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Bicyclo-GABA

Bicyclo-GABA Chemical Structure

CAS No. : 1615763-33-1

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Bicyclo-GABA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC50 of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α1β2γ2 GABAA receptors with an EC50 of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery[1].

体外研究
(In Vitro)

Bicyclo-GABA (0.1-10000 nM；3 min) 可强效抑制人源 BGT1 对 [3H]GABA 的摄取 (IC50 = 1.5 μM)[1]。
Bicyclo-GABA (0-10 μM) 是人 BGT1 的非转运型竞争性抑制剂 (KB = 0.47 μM)[1]。
Bicyclo-GABA (0.01-100 μM) 对人源 α1β2γ2 GABAA 受体具有激动活性 (EC50 = 5.1 μM)[1]。
Bicyclo-GABA 在基于细胞的 [3H]GABA 摄取测定实验中，可调节 BGT1 和 GAT3 突变体的抑制活性 (IC50 范围：0.040-610 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bicyclo-GABA 相关抗体:
分子量

141.17

Formula

C7H11NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bicyclo-GABA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Bicyclo-GABA1615763-33-1GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorα?β?γ? GABA? receptorsBGT1α?β?γ? GABA_A receptors[3H]GABAbrainGAT3 mutantsQ299peripheryE52Betaine/GABA Transporter 1Inhibitorinhibitorinhibit

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