Biotin-Vitamin B12  (Synonyms: Biotin-Cyanocobalamin B12)

Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas^[1][2].

Vitamin B12 是八种 B 族维生素之一。它通常参与人体所有细胞的代谢，尤其影响 DNA 的合成和调控，也参与脂肪酸 (尤其是奇数链脂肪酸) 的合成和能量生成。然而，Vitamin B12 的许多 (但并非全部) 功能可以通过足量的叶酸 (维生素B9) 来弥补，因为 Vitamin B12 用于在体内再生叶酸。大多数 Vitamin B12 缺乏症的症状实际上都是叶酸缺乏症的症状，因为它们包括恶性贫血和巨幼细胞增生症的所有症状，这些症状是由于身体缺乏足够的叶酸来生成甲基捕获引起的胸腺嘧啶，导致 DNA 合成不良而引起的。当叶酸充足时，所有已知的与 Vitamin B12 相关的缺乏症都会恢复正常，但与 Vitamin B12 依赖性酶甲基丙二酸单酰辅酶 A 变位酶和 5-甲基四氢叶酸-同型半胱氨酸甲基转移酶 (MTR) (也称为蛋氨酸合酶) 及其各自底物 (甲基丙二酸，MMA) 和同型半胱氨酸的积累密切相关的除外^[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1581.66

C₇₃H₁₀₂CoN₁₆O₁₆PS

固体

Brown to red

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Banerjee R, et al. The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.  [Content Brief]