2. Antibody-drug Conjugate/ADC Related Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Antibody-Drug Conjugates (ADCs) ROR
  4. BL20-MMAE

BL20-MMAE 是由 BL20 连接子与 Auristatin 类载荷 MMAE (HY-15162) 结合的偶联物。BL20-MMAE 通过 BL20 连接子能够连接抗 ROR1 抗体，发挥抗癌活性。

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BL20-MMAE

BL20-MMAE Chemical Structure

CAS No. : 2765612-38-0

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BL20-MMAE 相关抗体

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查看 ROR 亚型特异性产品:

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RORγ RORα RORβ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody with the Auristatin payload MMAE (HY-15162) via a BL20 linker[1].

体外研究
(In Vitro)

BL20-MMAE (10 mg/mL; 28°C) 可与 ROR1-4 抗体偶联，形成药物抗体比精确为 4.0 的纯化抗体药物偶联物 (ADC)[1]。
BL20-MMAE (10 mg/mL; 28°C) 可与 ROR1-12 抗体偶联，形成药物抗体精准比值为 4.0 的纯化 ADC[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BL20-MMAE 相关抗体:
体内研究
(In Vivo)

BL20-MMAE (以 ROR1-12-BL20E 形式给药) (5 mg/kg；静脉注射；第 0 天和第 4 天) 可在 JeKo-1 白血病异种移植模型中实现 92%的肿瘤生长抑制率，6 只小鼠中有 1 只出现肿瘤部分消退[1]。
BL20-MMAE (以 ROR1-12-BL20E 形式给药) (5 mg/kg；静脉注射；每周 1 次；共 3 剂) 对 MDA-MB-231 乳腺癌异种移植物的肿瘤生长抑制率达 49%[1]。
BL20-MMAE (以 ROR1-4-BL20E 形式给药)(5 mg/kg；静脉注射；每周 1 次；共 3 剂) 在 MDA-MB-231 乳腺癌异种移植模型中实现 39% 的肿瘤生长抑制[1]。
BL20-MMAE (以 ROR1-12-BL20E 形式给药) (5 mg/kg；静脉注射) 在 H1975 非小细胞肺癌异种移植物中实现 51% 的肿瘤生长抑制[1]。
BL20-MMAE (以 ROR1-4-BL20E 形式给药)(5 mg/kg；静脉注射) 可在 H1975 非小细胞肺癌异种移植模型中实现 69% 的肿瘤生长抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: tumor-bearing mice (implanted with JeKo-1 cells, tumors grown to ~100 mm3)[1]
Dosage: 5 mg/kg
Administration: i.v.; on day 0 and day 4
Result: Achieved a tumor growth inhibition (TGI) rate of 92% in JeKo-1 tumors by day 18, with 1 out of 6 mice showing partial tumor regression.
Resulted in a statistically significant reduction in tumor volume compared to solvent control (P < 0.0001).
Animal Model: tumor-bearing mice (implanted with MDA-MB-231 cells)[1]
Dosage: 5 mg/kg
Administration: i.v.; once weekly; 3 doses
Result: Achieved a tumor growth inhibition (TGI) rate of 49% in MDA-MB-231 tumors.\nAchieved a tumor growth inhibition (TGI) rate of 39% in MDA-MB-231 tumors.
Animal Model: tumor-bearing mice (implanted with H1975 cells, tumors grown to 100-150 mm3)[1]
Dosage: 5 mg/kg
Administration: i.v.
Result: Achieved a tumor growth inhibition (TGI) rate of 51% in H1975 tumors.\nAchieved a tumor growth inhibition (TGI) rate of 69% in H1975 tumors.
分子量

1963.30

Formula

C98H133F2N13O23S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BL20-MMAE 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BL20-MMAE2765612-38-0Antibody-Drug Conjugates (ADCs)RORAntibody-Drug ConjugatesRAR-related orphan receptorMDA-MB-231 breast cancer xenograftsBL20 linkerH1975 non-small cell lung cancer xenograftsROR1JeKo-1 leukemia xenograftsauristatin payload MMAEInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-177109
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