2. Metabolic Enzyme/Protease
  3. Lipocalin Family
  4. BPN-14136

BPN-14136 是一种口服有效的视黄醇结合蛋白 4 (RBP4) 抑制剂。BPN-14136 抑制视黄醇与 RBP4 的结合，其 IC50 为 12.8 nM。BPN-14136 可抑制视黄醇依赖性 RBP4-转甲状腺素蛋白的相互作用 (IC50 = 43.6 nM)，并在体内降低循环血浆中的 RBP4 水平。BPN-14136 可减少视网膜色素上皮细胞中细胞毒性双视黄醇的形成。BPN-14136 可用于萎缩性年龄相关性黄斑变性和斯塔加特病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

BPN-14136

BPN-14136 Chemical Structure

CAS No. : 1628945-93-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

BPN-14136 相关抗体

Top Publications Citing Use of Products

查看 Lipocalin Family 亚型特异性产品:

查看所有亚型
Retinol Binding Protein

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC50 of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction (IC50 = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease[1].

体外研究
(In Vitro)

BPN-14136 (Compound 33) (10 μM; 30 min) 在人源和大鼠肝微粒体实验中表现出极佳的稳定性，在 10 μM 浓度下孵育 30 分钟后，剩余率分别为 94% 和 93%[1]。
BPN-14136 具有良好的体外 ADMET 特征，包括高溶解度、极低的肝脏清除率、无显著的 CYP 或 hERG 抑制作用、高血浆蛋白结合率以及高 MDR1-MDCK 通透性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BPN-14136 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax T1/2 AUClast AUCINF_obs Bioavailability C0 CL Vss
Rat[1] 5.1 μmol/Kg i.v. / / 22.0 h 795 μM·h 1017 μM·h / 58.6 μM 5.06 mL/min/kg 156 mL/kg
Rat[1] 12.7 μmol/Kg p.o. 62.2 μM 2.67 h 38.8 h 2011 μM·h 3636 μM·h 143 % / / /
体内研究
(In Vivo)

BPN-14136 (Compound 33) (5 mg/kg；口服；每日单次给药，连续 7 天) 可显著降低血浆 RBP4 水平，单次给药后降低 85%，连续 7 天每日给药后降低 95%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, adult, drug-naive)[1]
Dosage: 5 mg/kg (single dose); 5 mg/kg (7-day daily dosing)
Administration: p.o.; single dose; 7 days
Result: Induced an 85% maximum decrease in plasma RBP4.
Induced an approximately 95% reduction in plasma RBP4.
分子量

391.39

Formula

C20H20F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BPN-14136 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPN-141361628945-93-6BPN14136BPN 14136Lipocalin Familytransthyretinretinal pigment epitheliumrat liver microsomeCYPhERGRetinol Binding Protein 4RBP4Stargardt diseasehuman liver microsomeatrophic age-related macular degenerationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
BPN-14136
目录号：
HY-182385
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z