2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 degrader-7

BRD4 degrader-7 (Compound ZZ1) 是依赖于 CTLH 的 BRD4 降解剂和 c-Glue，其 DC50 为 489 nM。BRD4 degrader-7 可在细胞内转化为亚磺酸衍生物，与 YPEL5 的碱性口袋相互作用，介导 BRD4 BD1 与 CTLH E3 泛素连接酶的 YPEL5 亚基形成桥接，进而促进三元复合物的形成。BRD4 degrader-7 可用于尤因肉瘤、白血病的研究。

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BRD4 degrader-7

BRD4 degrader-7 Chemical Structure

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BRD4 degrader-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 degrader-7 (Compound ZZ1) is a CTLH-dependent BRD4 degrader and c-Glue with a DC50 of 489 nM. BRD4 degrader-7 converts to a sulfinic acid derivative inside cells, interacts with the basic pocket of YPEL5, mediates the bridging of BRD4 BD1 to the YPEL5 subunit of the CTLH E3 ubiquitin ligase, and thereby promotes the formation of a ternary complex. BRD4 degrader-7 can be used in research on Ewing's sarcoma and leukemia[1].

IC50 & Target[1]

BRD4

489 nM (DC50)

体外研究
(In Vitro)

BRD4 degrader-7 (ZZ1) (10-10000 nM; 5 h) 可通过非 CRL E3 连接酶通路，在 Jurkat 细胞中强效诱导 BRD4 的蛋白酶体依赖性降解，其 DC50 为 502 nM[1]。
BRD4 degrader-7 (10-10000 nM; 5 h) 可诱导 Jurkat 细胞中 BRD4 降解，其 DC50 为 489 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 degrader-7 相关抗体:
分子量

658.16

Formula

C30H29ClFN5O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 degrader-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

BRD4 degrader-7Epigenetic Reader DomainBET family proteinBRD2Jurkat cellsleukemiaBRD4WDR26YPEL5BRD3CTLH E3 ubiquitin ligaseewing sarcomaInhibitorinhibitorinhibit

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