2. Neuronal Signaling
  3. Amyloid-β
  4. BTA-EG6

BTA-EG6 是一种可穿透血脑屏障的聚集态 β-淀粉样蛋白 (Aβ) 肽结合剂，其与 Aβ1-42 的 Kd 为 290 nM。BTA-EG6 可与聚集态 Aβ 结合并形成抗蛋白涂层，阻断 Aβ 与过氧化氢酶之间的相互作用。BTA-EG6 可保护神经母细胞瘤细胞免受 Aβ 诱导的毒性与氧化应激损伤，并抑制 Aβ 诱导的细胞内过氧化氢 (H2O2) 水平升高。BTA-EG6 可用于阿尔茨海默病 (AD) 的相关研究。

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BTA-EG6

BTA-EG6 Chemical Structure

CAS No. : 921193-29-5

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BTA-EG6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTA-EG6 is a brain-penetrant aggregated amyloid-β (Aβ) peptide binder with a Kd of 290 nM for Aβ1-42. BTA-EG6 binds to aggregated Aβ and forms protein-resistive coatings that block interactions between Aβ and catalase. BTA-EG6 protects neuroblastoma cells from Aβ-induced toxicity and oxidative stress, and inhibits Aβ-induced increases in cellular hydrogen peroxide (H2O2) levels. BTA-EG6 can be used for the research of alzheimer’s disease (AD)[1].

体外研究
(In Vitro)

BTA-EG6 (0-500 μM; 24 h) 对分化的人神经母细胞瘤 SH-SY5Y 细胞具有毒性，处理 24 h 后的 IC50 为 69 ± 5 μM[1]。
BTA-EG6 (过夜) 在孵育过夜后以 290 ± 60 nM 的 Kd 值与聚集态 β-淀粉样蛋白 1-42 肽结合[1]。
BTA-EG6 (5-20 μM; 24 h) 可呈剂量依赖性地保护分化的人神经母细胞瘤 SH-SY5Y 细胞免受 25 μM 的 amyloid-β 1-42 诱导的毒性[1]。
BTA-EG6 (1-40 μM; 24 h) 可剂量依赖性地降低分化的人神经母细胞瘤 SH-SY5Y 细胞中 25 μM 的 amyloid-β 1-42 诱导的过氧化氢 (H2O2) 水平，在 40 μM 处理 24 h 后可使该水平恢复正常[1]。
BTA-EG6 (40 μM; 12 h) 可抑制过氧化氢酶与固定化聚集态 amyloid-β 1-42 肽的相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BTA-EG6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Differentiated SH-SY5Y human neuroblastoma cells exposed to aggregated Aβ 1-42 peptides
Concentration: 5, 10, 20 μM (in presence of 25 μM aggregated Aβ 1-42)
Incubation Time: 24 h
Result: Increased cell viability in a dose-dependent manner, over 80% at 20 μM, which was statistically significant compared to cells treated with Aβ alone.

Immunofluorescence[1]

Cell Line: SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 12 h
Result: Reduced fluorescence intensity of amyloid-β 1-42.
体内研究
(In Vivo)

BTA-EG6 可穿透血脑屏障，降低体内 Aβ 水平，并改善阿尔茨海默病小鼠模型的记忆与学习能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

504.64

Formula

C26H36N2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTA-EG6 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

BTA-EG6921193-29-5Amyloid-ββ-amyloid peptideAβAbetahydrogen peroxideblood-brain barrieroxidative stressmouse model of Alzheimer's diseaseSH-SY5Y human neuroblastoma cellsamyloid-β (Aβ) peptideAlzheimer’s diseasecatalaseneuroblastoma cellsDiPhyPC planar lipid bilayersInhibitorinhibitorinhibit

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