2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. BW A4C

BW A4C 是一种选择性 5-脂氧合酶 (5-LO) 抑制剂。BW A4C 也是 Gaeumannomyces graminis 亚麻酸 8R-双加氧酶的抑制剂，IC50 为 0.2 μM。BW A4C 可用于哮喘等疾病的研究。

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BW A4C

BW A4C Chemical Structure

CAS No. : 106328-57-8

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BW A4C 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma[1][2].

IC50 & Target[1]

5-LO

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
PMNL IC50
0.05 μM
Compound: BWA4C
Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
[PMID: 22551629]
PMNL IC50
0.11 μM
Compound: 8, BW-A4C
Inhibition of 5-LO in PMNL cells
Inhibition of 5-LO in PMNL cells
[PMID: 19053751]
RBL-1 IC50
100 nM
Compound: 4 (BW-A4C)
Compound was tested for in vitro inhibition on broken human PMNL
Compound was tested for in vitro inhibition on broken human PMNL
[PMID: 8709092]
U-937 IC50
> 30 μM
Compound: BWA4C
Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
[PMID: 22551629]
分子量

283.32

Formula

C17H17NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BW A4C 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BW A4C106328-57-8LipoxygenaseLOX5-LOGaeumannomyces graminisasthmaInhibitorinhibitorinhibit

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产品名称：
BW A4C
目录号：
HY-136923
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