2. Others Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reference Standards Reactive Oxygen Species (ROS)
  4. CADD522 (Standard)

CADD522 (Standard) 是 CADD522 (HY-107999) 的分析标准品。本产品用于研究及分析应用。CADD522 是一种 RUNX2-DNA 结合抑制剂 (下调 RUNX2 介导的下游靶基因的转录)，其 IC50 值为 10 nM。CADD522 还可通过增加线粒体驱动的细胞 ROS 水平发挥其抗肿瘤活性。CADD522 能抑制体内原发肿瘤的生长和免疫受损小鼠肺部肿瘤细胞的实验性转移，可用于癌症的研究。

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CADD522 (Standard)

CADD522 (Standard) Chemical Structure

CAS No. : 199735-88-1

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CADD522 (Standard) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CADD522 (Standard) is the analytical standard of CADD522 (HY-107999). This product is intended for research and analytical applications. CADD522 is a RUNX2-DNA binding inhibitor (downregulates RUNX2-mediated transcription of downstream target genes), with an IC50 of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer[1][2].

IC50 & Target

RUNX2-DNA binding[1]
分子量

326.17

Formula

C15H13Cl2NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CADD522 (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CADD522 (Standard)199735-88-1Reference StandardsReactive Oxygen Species (ROS)breast cancerMCF7MDA-468MDA-231MCF7-tet-offT47D-RUNX2Inhibitorinhibitorinhibit

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