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CAII-IN-13 是一种人类碳酸酐酶抑制剂，对人类碳酸酐酶 II 的 Ki 为 65.9 nM，对人类碳酸酐酶 I 的 Ki 为 968.4 nM。CAII-IN-13 可在功能上抑制人类碳酸酐酶 II 和人类碳酸酐酶 I 的催化活性。CAII-IN-13 符合类药五原则，提示其具有与 in vivo 生物利用度相关的理化性质和药代动力学特征。

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CAII-IN-13

CAII-IN-13 Chemical Structure

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CAII-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAII-IN-13 is a human carbonic anhydrase inhibitor with a Ki of 65.9 nM for human carbonic anhydrase II and 968.4 nM for human carbonic anhydrase I.CAII-IN-13 functionally inhibits catalytic activity of human carbonic anhydrase II and human carbonic anhydrase I.CAII-IN-13 complies with Lipinski's rule of five, indicating physiochemical and pharmacokinetic properties associated with in vivo bioavailability[1].

体外研究
(In Vitro)

CAII-IN-13 (0.01 nM-0.1 mM; 15 min at room temperature) 可强效抑制重组人碳酸酐酶 II，其 Ki 值为 65.9 nM；同时可抑制重组人碳酸酐酶 I，其 Ki 值为 968.4 nM[1]。
CAII-IN-13 可通过氢键和 Zn2+ coordination[1]与重组人碳酸酐酶 I 及碳酸酐酶 II 紧密结合，结合亲和力分别为-10.7 kcal/mol 和-10.98 kcal/mol。
CAII-IN-13 表现出良好的预测药代动力学特性，包括较高的胃肠道吸收、0.55 的生物利用度评分，且无血脑屏障通透性，仅存在 1 项 Lipinski 五规则偏差[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAII-IN-13 相关抗体:
分子量

464.97

Formula

C24H21ClN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAII-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAII-IN-13human carbonic anhydrase I,recombinant human carbonic anhydrase I,recombinant human carbonic anhydrase II,Lipinski's rule of five,human carbonic anhydrase IIInhibitorinhibitorinhibit

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目录号：
HY-181238
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