2. Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation
  3. Glutathione S-transferase Influenza Virus Interleukin Related IFNAR
  4. Cappariloside A

Cappariloside A 是一种杀幼虫剂，对埃及伊蚊幼虫表现出杀幼虫活性，可降低幼虫谷胱甘肽-S-转移酶 (Glutathione S-transferase) 活性。 Cappariloside A 还具有抗病毒活性，可降低细胞中磷酸化 STAT1 水平，抑制流感病毒 (Influenza Virus) H1N1、H3N2、PIV3 和 ADV 的复制，并下调 IL-6、IP-10、MIG、RANTES/CCL-5、IFN-β 及 IL-29 的表达。 Cappariloside A 抑制小鼠肺适应型流感毒株诱导的炎症反应。 Cappariloside A 可用于杀幼虫、流感病毒感染相关研究。

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Cappariloside A

Cappariloside A Chemical Structure

CAS No. : 229483-41-4

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Cappariloside A 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Cappariloside A is a larvicide that exhibits larvicidal activity against Aedes aegypti larvae and reduces larval glutathione-S-transferase activity. Cappariloside A also possesses antiviral activity, decreases the level of phosphorylated STAT1 in cells, inhibits the replication of influenza viruses H1N1, H3N2, PIV3 and ADV, and downregulates the expression of IL-6, IP-10, MIG, RANTES/CCL-5, IFN-β and IL-29. Cappariloside A suppresses the inflammatory response induced by mouse lung-adapted influenza virus strains. Cappariloside A can be used in studies related to larvicidal applications and influenza virus infection[1][2].

体外研究
(In Vitro)

Cappariloside A (Compound 1) (24-48 h) 对 3 龄埃及伊蚊幼虫具有杀幼虫活性，LC50 为 71.14 ppm[1]。
Cappariloside A (71.14 ppm; 24 h) 可降低存活的 3 龄埃及伊蚊幼虫体内谷胱甘肽-S-转移酶的活性[1]。
Cappariloside A (0-400 μg/mL; 72 h) 抑制甲型流感病毒 A/PR/8/34 (H1N1) 在 MDCK 细胞中的复制，其 IC50 为 115.25 μg/mL[2]。
Cappariloside A (48 h) 对 MDCK 细胞中的人流感病毒亚型 A/PR/8/34 (H1N1)、A/GZ/GIRD07/09 (H1N1 pdm2009) 和 A/HK/8/68 (H3N2) 具有强效抗病毒活性，IC50 分别为 288.03、362.18、375.73 μg/mL, SI 分别为 4.36、3.37、3.34[2]。
Cappariloside A 在 LLC-MK2 细胞中对 PIV3 表现出抗病毒活性 (IC50 = 757.86 μg/mL, SI = 1.32)，在 A549 细胞中对 ADV3 表现出抗病毒活性 (IC50 = 382.23 μg/mL, SI = 3.32)[2]。
Cappariloside A (0-4 mg/mL; 6-72 h) 抑制 16HBE 细胞中甲型流感病毒 A/PR/8/34 (H1N1) 的子代复制，且在低至 0.25 mg/mL 的剂量下即可抑制病毒诱导的 IL-6、IP-10、MCP-1 和 RANTES/CCL-5 的表达[2]。
Cappariloside A (0.25-2 mg/mL; 24, 48 h) 抑制 RAW264.7 细胞中甲型流感病毒 A/PR/8/34 (H1N1) 的子代复制，并在 1 mg/mL 和 0.5 mg/mL 浓度下抑制病毒诱导的 IP-10 和 RANTES/CCL-5 的表达[2]。
Cappariloside A (0-1 mg/mL; 24 h) 抑制禽流感病毒 H9N2 诱导的 16HBE 细胞中 IP-10 与 RANTES/CCL-5 的表达，但不抑制病毒复制[2]。
Cappariloside A (0-2 mg/mL; 24 h) 抑制 RAW264.7 细胞中 LPS (HY-D1056) 诱导的 IP-10、IL-6 及 RANTES/CCL-5 的表达，且不影响 TNF-α 水平[2]。
Cappariloside A (0-2 mg/mL; 6, 24, 48, 72 h) 可通过抑制病毒诱导的 STAT1 磷酸化、降低 IFN-β 和 IL-29 的表达、以及抑制 IFN-β 诱导的 IP-10 和 RANTES/CCL-5 表达，调控 16HBE 细胞中的宿主 IFN 信号通路[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cappariloside A 相关抗体:

ELISA Assay[2]

Cell Line: Human bronchial epithelial (16HBE) cells infected with avian influenza virus A/Chicken/Guangdong/1996 (H9N2)
Concentration: 1, 0.5, 0.25 mg/mL
Incubation Time: 24 h
Result: Significantly reduced H9N2-induced protein levels of IP-10 and RANTES/CCL-5 in a dose-dependent manner, despite no inhibition of H9N2 replication.

ELISA Assay[2]

Cell Line: Murine macrophage (RAW264.7) cells stimulated with lipopolysaccharide (LPS)
Concentration: 2, 1 mg/mL
Incubation Time: 24 h
Result: Significantly reduced LPS-induced protein levels of IP-10, IL-6, and RANTES/CCL-5 in a dose-dependent manner, with no effect on TNF-α levels.
体内研究
(In Vivo)

Cappariloside A (75-300 mg/kg·day；口服；每日 2 次；连续 5 天) 可剂量依赖性地抑制雌性 BALB/c 小鼠中流感诱导的炎症与肺损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6-8 weeks old)[2]
Dosage: 75-300 mg/kg·day
Administration: p.o.; twice daily; 5 days
Result: Inhibited influenza-induced weight loss at day 3, 5, and 7 post-infection at 300 mg/kg·day; inhibited influenza-induced weight loss at day 3 post-infection at 150 and 75 mg/kg·day.
Reduced pulmonary index by 50% at day 5 post-infection at 300 mg/kg·day; reduced pulmonary index by 30% at day 5 post-infection at 150 mg/kg·day; reduced pulmonary index by 20% at day 5 post-infection at 75 mg/kg·day.
Inhibited total protein concentration increase in bronchoalveolar lavage fluid (BALF) at day 3, 5, and 7 post-infection at 300 mg/kg·day; inhibited total protein concentration increase in BALF at day 3, 5, and 7 post-infection at 150 mg/kg·day; inhibited total protein concentration increase in BALF at day 3 and 5 post-infection at 75 mg/kg·day.
Reduced inflammatory cell infiltration, inflammatory area, and pathology score in lung tissue at 300 mg/kg·day.
Decreased total white cell counts in BALF at day 5 post-infection at 300, 150, and 75 mg/kg·day.
Inhibited influenza-induced IL-6 and IP-10 levels in BALF at day 3, 5, and 7 post-infection at 300 mg/kg·day; inhibited influenza-induced IL-6 and IP-10 levels in BALF at day 3 and 5 post-infection at 150 and 75 mg/kg·day.
分子量

334.32

Formula

C16H18N2O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cappariloside A 相关分类

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Keywords:

Cappariloside A229483-41-4Glutathione S-transferaseInfluenza VirusInterleukin RelatedIFNARGlutathione transferasesGSTsILInterferon-α/β receptorInterferon-alpha/beta receptorlarvicideAedes aegypti larvaeglutathione-S-transferaseinfluenza virusesBALB/c miceInhibitorinhibitorinhibit

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