2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. Cemtirestat

Cemtirestat (CMTI) 是一种羧甲基化噻三嗪并吲哚类醛糖还原酶 (ALR2) 抑制剂。Cemtirestat 可强效抑制大鼠眼晶状体 ALR2，其 IC50 为 0.116 μM，且对大鼠肾脏 ALR1 的选择性高达 302 倍。Cemtirestat 可用于晚期糖尿病并发症的研究。

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Cemtirestat

Cemtirestat Chemical Structure

CAS No. : 309283-89-4

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规格 价格 是否有货 数量
100 mg ￥546
In-stock
250 mg ￥930
In-stock
500 mg ￥1418
In-stock
1 g ￥2268
In-stock
5 g   询价  
10 g   询价  

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Cemtirestat 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications[1].

分子量

260.27

Formula

C11H8N4O2S
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

Cemtirestat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cemtirestat309283-89-4CMTIAldose Reductaserat eye lenslate diabetic complicationsaldose reductase (ALR2)rat kidney ALR1antioxidantInhibitorinhibitorinhibit

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目录号：
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