2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CK1γ-IN-1

CK1γ-IN-1 是一种非选择性 CK1 激酶抑制剂，对人源 CK1γ1、CK1γ2、CK1γ3 的 IC50 分别为 780 nM、570 nM 和 990 nM。CK1γ-IN-1 对多种激酶的非特异性结合，可能用于特异性 CK1γ 的生物学研究。

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CK1γ-IN-1

CK1γ-IN-1 Chemical Structure

CAS No. : 1397706-29-4

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CK1γ-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Casein Kinase 亚型特异性产品:

查看所有亚型
CK1 CK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CK1γ-IN-1 is a non-selective CK1 kinase inhibitor with IC50 values of 780 nM, 570 nM and 990 nM against human CK1γ1, CK1γ2, CK1γ3, respectively. The non-specific binding of CK1γ-IN-1 to multiple kinases enables its application in biological studies of specific CK1γ[1].
IC50 & Target

CK1γ1

780 nM (IC50)

CK1γ2

570 nM (IC50)

CK1γ3

990 nM (IC50)

体外研究
(In Vitro)

CK1γ-IN-1 (compound 1h) (0-10 μM; 2 h) 可在活 HEK293 细胞中强效结合并稳定所有三种亚型：CK1γ1、CK1γ2、CK1γ3，对应的 IC50 值分别为 780 nM、570 nM 和 990 nM[1]。
CK1γ-IN-1 可在无细胞放射分析中强效抑制 CK1γ1 (IC50=128 nM) 和 CK1γ2 (IC50=28 nM) 的酶活性，对 CK1γ3 的活性抑制作用较弱 (IC50=1661 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CK1γ-IN-1 相关抗体:
分子量

292.34

Formula

C17H16N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CK1γ-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK1γ-IN-11397706-29-4Casein KinaseHCMVkinaseCK1γ1CK1CK1γ2CK1γ3HEK293 cellsMOKLRP6HFF cellsInhibitorinhibitorinhibit

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