2. Anti-infection
  3. HIV
  4. CK147

CK147 是一种 Sec61α 转运体抑制剂，通过结合并抑制内质网膜上的 Sec61 蛋白转位通道，从而阻断蛋白质的共翻译转运。CK147 具有强效的 CD4 下调活性，其 IC₅₀ 为 0.04 µM。CK147 可阻止 HIV 进入宿主细胞，具有显著的细胞毒性。CK147 可用于 HIV 感染的相关研究。

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CK147

CK147 Chemical Structure

CAS No. : 1883356-12-4

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CK147 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection[1][2].

体外研究
(In Vitro)

CK147 (0.01-100 μM; 18 h) 可在瞬时转染的 HEK293T 细胞中强效下调人 CD4 的表达，其 IC50 为 0.04 μM，最大抑制率可达 95%[1]。
CK147 (0.01-100 μM; 72 h) 对 HEK293T 细胞具有细胞毒性，其 CC50 为 0.36 μM，可显著降低处理 72 小时后的细胞增殖水平[1]。
CK147 (0.01-100 μM; 72 h) 可抑制野生型 HCT116 细胞的增殖，其 CC50 为 0.48 μM，但对 CK147 耐药型 HCT116 克隆的增殖无影响，该耐药克隆的 CC50 值＞50 μM[1]。
CK147 可下调 CD4 表达，其 IC50 为 0.058 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CK147 相关抗体:

Cell Proliferation Assay[1]

Cell Line: human embryonic kidney (HEK) 293T cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time: 72 h
Result: Reduces HEK293T cell proliferation in a concentration-dependent manner, with a cytotoxic concentration (CC50) of 0.36 μM.
Reduces proliferation to ≤ 10% of DMSO control levels at concentrations ≥ 0.1 μM.

Cell Proliferation Assay[1]

Cell Line: wild-type and CK147-resistant HCT116 human colon cancer cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time: 72 h
Result: Inhibits proliferation of wild-type HCT116 cells, with a CC50 of 0.48 μM.
Shows no effect on proliferation of three CK147-resistant HCT116 clones (10, 13, 16), which have CC50 values > 50 μM and proliferation remaining near 100% of DMSO control across all tested concentrations.
分子量

616.88

Formula

C32H48N4O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CK147 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK1471883356-12-4CK 147CK-147HIVHuman immunodeficiency virusCD4HCT116 cellsSec61α channelSec61α transloconprotein translocationcotranslational translocationplug helixHEK293T cellslateral gate helicesInhibitorinhibitorinhibit

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产品名称：
CK147
目录号：
HY-182690
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