2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. CL-283796

CL-283796 是一种强效的、具有口服有效性的酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 抑制剂。CL-283796 能在非洲绿猴中降低低密度脂蛋白 (LDL) 胆固醇，且不影响胆固醇吸收。CL-283796 可用于高胆固醇血症的相关研究。

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CL-283796

CL-283796 Chemical Structure

CAS No. : 107376-72-7

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CL-283796 相关抗体

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查看 Acyltransferase 亚型特异性产品:

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ACAT1 ACAT2 MGAT2 ACAT DGAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research[1].

IC50 & Target[1]

ACAT

 

体内研究
(In Vivo)

CL-283796 (口服给药，每日 10 mg/kg 持续 5 周，每日 30 mg/kg 再持续 5 周) 在非洲绿猴模型中可降低低密度脂蛋白胆固醇，且不影响胆固醇吸收[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult African green monkeys fed an atherogenic diet for approximately 6 weeks[1]
Dosage: 10 and 30 mg/kg
Administration: p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks
Result: Resulted in a 24.1% reduction in total plasma cholesterol after 30 days (10 mg/kg dose).
Resulted in significant reductions in LDL cholesterol but non-significant effects on VLDL cholesterol values.
Showed no significant effects on plasma triglyceride values, HDL cholesterol, and apolipoproteins A-I, B and E levels.
Decreased the total plasma cholesterol (TPC)/HDL cholesterol ratios by 40% after 10 weeks.
Showed no significant effect on cholesterol absorption.
Did not affect body weights.
分子量

457.09

Formula

C28H41ClN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CL-283796 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL-283796107376-72-7CL283796CL 283796AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseacyltransferaseLDL cholesterolcholesterol absorptionhypercholesterolemiaInhibitorinhibitorinhibit

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产品名称：
CL-283796
目录号：
HY-19251
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