2. GPCR/G Protein Apoptosis
  3. Amylin Receptor Apoptosis
  4. Cloridarol

Cloridarol 是一种人胰岛淀粉样蛋白肽 (hIAPP) 抑制剂，可防止其自身异常错误折叠和聚集。Cloridarol 能够提高细胞活力，抑制细胞凋亡 (apoptosis)，并保护胰岛 β 细胞免受 hIAPP 诱导的细胞毒性。Cloridarol 可用于 2 型糖尿病 (T2D) 的研究。

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Cloridarol

Cloridarol Chemical Structure

CAS No. : 3611-72-1

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Cloridarol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cloridarol is a human islet amyloid peptide (hIAPP) inhibitor that prevents its abnormal misfolding and aggregation. Cloridarol can increase cell viability, inhibit apoptosis, and protect islet β-cells from hIAPP-induced cell toxicity. Cloridarol can be used for the research of type 2 diabetes (T2D)[1].

体外研究
(In Vitro)

Cloridarol (25-125 µM；0-20 小时) 以剂量依赖方式抑制 hIAPP 的聚集，可使最终纤维形成减少高达 55.6%[1]。
Cloridarol (125 µM；5-24 小时) 可改变 hIAPP 聚集体的形态，抑制其二级结构向 β-折叠转变，维持无规卷曲结构 [1]。
Cloridarol (125 µM；0-25 小时) 可抑制由滞后期和早期生长期种子引发的 hIAPP 聚集，但对平衡期原纤维无此抑制作用 [1]。
Cloridarol (25-125 µM；24-48 小时) 可保护 RIN-m5F 细胞免受 hIAPP 诱导的毒性，表现为细胞活力增加和细胞凋亡减少[1]。
Cloridarol (50 µM；0-900 分钟) 可减少 hIAPP1−37 诱导的大单层囊泡 (LUV) 膜泄漏，这与其对 hIAPP 毒性的保护作用有关 [1]。
Cloridarol 与 hIAPP 五聚体的 C 端 β-折叠区域结合，破坏其结构并降低 β-折叠含量，从而抑制聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cloridarol 相关抗体:

Cell Viability Assay[1]

Cell Line: RIN-m5F pancreatic β-cells
Concentration: 25, 50, 125 μM
Incubation Time: 24, 48 h
Result: Showed concentration- and time-dependent cytotoxicity.
Increased cell viability from 55% to 70% (24 h) at 50 μM when combined with hIAPP (25 μM).

Apoptosis Analysis[1]

Cell Line: RIN-m5F pancreatic β-cells
Concentration: 25, 50, 125 μM
Incubation Time: 24, 48 h
Result: Showed concentration- and time-dependent cytotoxicity.
Dcreased cell apoptosis from 45% to 17% (24 h) at 50 μM when combined with hIAPP (25 μM)).
分子量

258.70

Formula

C15H11ClO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cloridarol 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Cloridarol3611-72-1Amylin ReceptorApoptosisAMYRhydrogen bondinghIAPPislet β-cellshydrophobic interactionsπ-π stackingLUVshuman islet amyloid peptidecardiovascular diseaseC-terminal β-sheet regiontype ii diabeteshIAPP oligomersRIN-m5F cellsInhibitorinhibitorinhibit

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