2. 多肽产品
  3. 多肽及其衍生物
  4. CLPVASC

CLPVASC 是一种肾脏靶向环肽，可优先分布于肾脏组织，具有增强纳米载体肾脏靶向性的效用。CLPVASC 展示于 PEG-b-PPS 胶束表面时可优先分布于肾脏。CLPVASC 可用于急性肾损伤的研究。

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Custom Peptide Synthesis

CLPVASC

CLPVASC Chemical Structure

CAS No. : 3106628-26-3

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CLPVASC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury[1].

体内研究
(In Vivo)

CLPVASC (摩尔比为 1%) 与摩尔比为 1%的 CYNTTTHRC 共展示的胶束 (17 mg/mL MC; i.v. (retro-orbital route); single dose) 在缺血再灌注损伤小鼠肾脏中的摄取量比对侧对照肾脏高 3.4 倍，且向其他器官的脱靶分布减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (female, 17.5 to 22.5 weeks old, unilateral renal ischemia-reperfusion injury)[1]
Dosage: MC loaded with 0.3% w/w DiI, displaying CLPVASC at a 1% molar ratio alongside CYNTTTHRC at a 1% molar ratio, at an overall MC concentration of 17 mg/mL
Administration: i.v. (retro-orbital route); single dose
Result: Achieved 3.4-fold higher uptake in the ischemia-reperfusion injured kidney compared to the contralateral control kidney.
Showed 2.3-fold higher uptake in the injured kidney than in the lungs.
Exhibited 67% higher uptake in the injured kidney than that of non-targeted MC.
分子量

689.84

Formula

C28H47N7O9S2
CAS 号
Sequence

cyclo(Cys-Leu-Pro-Val-Ala-Ser-Cys)
Sequence Shortening

cyclo(CLPVASC)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CLPVASC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLPVASC3106628-26-3cyclo(CLPVASC)Otherskidney-targeting cyclic peptideacute kidney injuryC57BL/6J mice
Inhibitorinhibitorinhibit

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