2. Anti-infection
  3. Flavivirus Dengue Virus Virus Protease
  4. CN-716 dihydrochloride

CN-716 dihydrochloride 是一种具有抗病毒活性的可逆共价型黄病毒 NS2B·NS3 蛋白酶抑制剂。CN-716 dihydrochloride 能有效抑制登革热病毒 (DENV2)、西尼罗河病毒 (WNV) 和寨卡病毒 (ZIKV) 的复制。CN-716 dihydrochloride 对上述三种病毒蛋白酶的 IC50 值分别为 0.066 μM、0.11 μM 和 0.25 μM，Ki 值分别为 0.051 μM、0.082 μM 和 0.04 μM。CN-716 dihydrochloride 可用于研究登革热、西尼罗河热及寨卡病毒感染机制。

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CN-716 dihydrochloride

CN-716 dihydrochloride Chemical Structure

CAS No. : 2077164-48-6

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CN-716 dihydrochloride 相关抗体

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  • 生物活性

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生物活性

CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC50 values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the Ki values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection[1][2].

体外研究
(In Vitro)

CN-716 dihydrochloride 可抑制登革病毒、西尼罗河病毒在细胞培养中的复制，其 EC50 为 30 μM 和 38 μM[2]。
CN-716 dihydrochloride (up to 100 μM) 在细胞培养中，浓度最高达 100 μM 时未表现出细胞毒性[2]。
CN-716 dihydrochloride 可结合处于闭合活性构象的西尼罗河病毒 NS2B·NS3 蛋白酶，与 Ser135 形成共价键，并与该蛋白酶的亚位点形成多种特异性非共价相互作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CN-716 dihydrochloride 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: normal cell
Concentration: 100 μM
Incubation Time: /
Result: Showed the CC50 >100 μM.
分子量

527.25

Formula

C22H33BCl2N6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CN-716 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CN-7162077164-48-6CN716CN 716FlavivirusDengue VirusVirus ProteaseDENVZika virusgZiPro constructdengue virus serotype 2Zika virus infectionactive-site serine residuesWest Nile virusflavivirus NS2B·NS3 proteasedengue virus infectionWest Nile virus infectionInhibitorinhibitorinhibit

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CN-716 dihydrochloride
目录号：
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