2. Immunology/Inflammation
  3. CD47
  4. CO-1

CO-1 是一种 IgG4 抗 CD47 抗体。CO-1 不仅增强巨噬细胞的吞噬活性，还通过 CD47 的交联直接诱导癌细胞发生一种独特且快速的程序性细胞死亡 (PCD)。CO-1 对血液系统恶性肿瘤 (如急性淋巴细胞白血病) 具有抗肿瘤活性。

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CO-1

CO-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

CO-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CO-1 is an IgG4 anti-CD47 antibody. CO-1 not only enhances themacrophage phagocytosis activity but also induces a unique and fast form of programmed celldeath (PCD) in cancer cells directly through ligation of CD47. CO-1 has anticancer activity against hematologic malignancies such as acute lymphoblastic leukemia[1].

同型

Human IgG4 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

CD47
体外研究
(In Vitro)

CO-1 可在几种源自血液系统恶性肿瘤的细胞系 (Jurkat、MOLT-4 和 REH) 中诱导快速 (3 小时内) 且强效 (≥40%) 的程序性细胞死亡[1]。
CO-1 不会引起红细胞的血凝反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CO-1 相关抗体:
体内研究
(In Vivo)

CO-1 可改善携带人 B 细胞前体急性淋巴细胞白血病异种移植物的 NSG 小鼠症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

961  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CO-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CO-1CO1CO 1CD47Cluster of Differentiation 47MER6OA3CD47-SIRPα interactionDEU1hematologic malignanciesprogrammed cell deathred blood cellsxenograft modelNSG miceRBCmacrophage phagocytosisCD47 ligandJurkathematological cancer cellscancer cellshuman B cell precursor acute lymphoblastic leukemiaMalT AInhibitorinhibitorinhibit

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产品名称：
CO-1
目录号：
HY-P991924
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