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  3. Copper Fluor-4 (solution)

Copper Fluor-4 (solution) (CF4 (solution)) 是一种基于对甲酚染料支架的 Cu+ (一价铜离子) 特异性荧光探针。Copper Fluor-4 solution 具有高铜选择性,Kd 值为 2.9×10?13 M,特别是相对于锌和铁,以及丰富的细胞碱金属和碱土金属。Copper Fluor-4 solution 在 6 至 8 之间的生理相关 pH 范围内保持稳定 (激发波长为 415 nm,发射波长为 660 nm)。
溶剂及浓度:DMSO:5 mM

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Copper Fluor-4 (solution)

Copper Fluor-4 (solution) Chemical Structure

CAS No. : 2365532-64-3

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生物活性

Copper Fluor-4 (solution) (CF4 (solution)) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 solution has high copper selectivity with a Kd value of 2.9×10?13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 solution is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission)[1][2][3].
Solvent and concentration: DMSO: 5 mM

体外研究
(In Vitro)

Copper Fluor-4 (0.8 μM, 10 分钟) 显示出铜在 PC-12 衍生神经元细胞体区域的定位,这包括核旁高尔基区域的定位[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Copper Fluor-4 (2 μM, 24 小时) 可用于评估小型生物体 (如斑马鱼胚胎) 中可变铜分布的变化[1]
Copper Fluor-4 (10 μM, 3 小时) 可用于评估蠕虫中不稳定的铜水平,其 Kd 值为 2.9×10?13 M,适用于1:1 的铜:探针化学计量,这与通过可逆铜结合来监测不稳定的铜库非常匹配,而不会耗尽体内的总铜储藏[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

749.05

Formula

C38H47F3N2O2S4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Copper Fluor-4 (solution)
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