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  3. Drug Derivative
  4. Cryptophycin 52

Cryptophycin 52 (LY355703) 是一种合成的 16 元环酯肽化合物，是海洋天然产物 Cryptophycin 1 的衍生物，具有抗肿瘤活性。Cryptophycin 52 能诱导细胞 G2/M 期阻滞。Cryptophycin 52 对 Paclitaxel (HY-B0015) 和 Doxorubicin (HY-15142A) 耐药的实体瘤也有效。Cryptophycin 52 可用于癌症研究，如多药耐药肿瘤。

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Cryptophycin 52

Cryptophycin 52 Chemical Structure

CAS No. : 186256-67-7

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Cryptophycin 52 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cryptophycin 52 (LY355703) is a synthesized 16-membered cyclic ester peptide compound and is a derivative of marine natural product cryptophycin 1 with antitumor activity. Cryptophycin 52 can induce cells G2/M phase arrest. Cryptophycin 52 is also effective for solid tumors that are resistant to Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cryptophycin 52 can be used for the research of cancer, such as multidrug-resistant tumor[1].

体外研究
(In Vitro)

Cryptophycin 52 对多种肿瘤细胞具有抑制活性，对 HL-60 细胞的 IC50 值为 24.8 pmol/L[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cryptophycin 52 相关抗体:
分子量

669.20

Formula

C36H45ClN2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cryptophycin 52 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cryptophycin 52186256-67-7LY355703Cryptophycin52Cryptophycin-52LY 355703LY-355703Drug DerivativeDrug derivativeInhibitorinhibitorinhibit

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