2. GPCR/G Protein Immunology/Inflammation
  3. CCR CXCR
  4. CXCR2 antagonist 10

CXCR2 antagonist 10 (Compound 10b) 是一种 CCR2 拮抗剂，其 IC50 为 0.48 μM。CXCR2 antagonist 10 对 CXCR2/CCR7 也有拮抗活性，其 IC50 分别为 4.18 和 2.07 μM。CXCR2 antagonist 10 可用于癌症研究。

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CXCR2 antagonist 10

CXCR2 antagonist 10 Chemical Structure

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CXCR2 antagonist 10 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

查看 CXCR 亚型特异性产品:

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXCR2 antagonist 10 (Compound 10b) is a CCR2 antagonist with an IC50 of 0.48 μM. CXCR2 antagonist 10 also exhibits antagonistic activity against CXCR2/CCR7, with IC50 values of 4.18 μM and 2.07 μM, respectively. CXCR2 antagonist 10 is applicable for cancer research[1].

IC50 & Target[1]

CCR2

0.48 μM ()

CCR7

2.07 μM ()

CXCR2

4.18 μM ()

药代动力学
(Parmacokinetics)
Species Dose Route Cmax AUC0-last CL Vz T1/2 Tmax Bioavailability
Rat[1] 1 mg/kg i.v. 3154 ng/mL 3487 ng·h/mL 286 mL/h/kg 504 mL/kg 1.2 h / /
Rat[1] 1 mg/kg i.v. 3154 ng/mL 3487 ng·h/mL 286 mL/h/kg 504 mL/kg 1.2 h / /
Rat[1] 5 mg/kg i.g. 3920 ng/mL 28867 ng·h/mL / / 2.16 h 0.25 h 165 %
Rat[1] 5 mg/kg i.g. 3920 ng/mL 28867 ng·h/mL / / 2.16 h 0.25 h 165 %
分子量

384.38

Formula

C15H15F3N6OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CXCR2 antagonist 10 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR2 antagonist 10CCRCXCRCC chemokine receptorCXC chemokine receptorsC-X-C motif chemokine receptorsCCR7CCR2breast cancercolorectal cancerCXCR2non-small lung canceresophageal squamous cell cancergastric cancerprostate cancerhead and neck cancerInhibitorinhibitorinhibit

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产品名称：
CXCR2 antagonist 10
目录号：
HY-181681
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