Cyetpyrafen 

Cyetpyrafen is a pyrazole insecticide/acaricide with broad-spectrum insecticidal activity. Cyetpyrafen binds to DhelOBP4 (K_i = 4.95 μM) and DhelOBP21 (K_i = 5.51 μM) to mediate olfactory recognition in *Cryptolaemus montrouzieri*. Cyetpyrafen induces dose-dependent electroantennogram responses in *Cryptolaemus montrouzieri* and exhibits repellent effects on the species. Cyetpyrafen has bioaccumulative properties, is rapidly and passively absorbed by the roots of lettuce and rice, reaches a steady state within 24 h, preferentially accumulates in roots, and shows limited xylem/phloem translocation^[1][2].

Cyetpyrafen (1.12 mg/L; 1-96 h) 可被水稻和生菜的根系快速吸收，在 24 h 内达到稳态；其优先在根系中积累 (水稻的平均 RCF 为 1290 mL/g，生菜的平均 RCF 为 1730 mL/g)，向地上部的转运能力较弱，且从生菜根系中的清除速度慢于水稻根系^[2]。
Cyetpyrafen (5 mg/L; 3-96 h) 不会在水稻幼苗中发生韧皮部介导的转运，因为它无法从暴露处理的根部迁移至未暴露处理的根部或地上部分^[2]。
Cyetpyrafen (1.12 mg/L; 24-96 h) 暴露会显著提高水稻和生菜根系中 CYP450、POD、CarE、GT 和 GST 的活性，表明这些酶介导了 cyetpyrafen 在植物体内的代谢转化^[2]。
Cyetpyrafen 被预测对鱼类具有极高毒性，对水蚤和绿藻具有高毒性；其多个 I 相代谢物 (M-391, M-409-1/2, M-407) 表现出相似的生态毒性水平，而 II 相代谢物的毒性则有所降低^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyetpyrafen (1-100 mg/L; 局部施用) 可通过作用于 DhelOBP4 和 DhelOBP21，在成虫大唼蜡甲中引发剂量依赖性的驱避效应和 EAG 反应；在敲低这两种气味结合蛋白后，成虫对所有测试浓度的 Cyetpyrafen 的嗅觉敏感性均显著降低^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

393.53

C₂₄H₃₁N₃O₂

1253429-01-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mao Z, et al. Cyetpyrafen, chlorfenapyr and spirodiclofen affect the olfactory recognition of Dastarcus helophoroides by acting on DhelOBP4 and DhelOBP21. Pestic Biochem Physiol. 2025;214:106568.  [Content Brief]

  [2]. Li R, et al. Insight into the uptake and metabolism of a new insecticide cyetpyrafen in plants. Environ Int. 2022;169:107522.  [Content Brief]