2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. CZh226 hydrochloride

CZh226 hydrochloride 是一种强效且有选择性的 PAK4 抑制剂，其 IC50 为 18 nM，对 PAK1 选择性为 346 倍。CZh226 hydrochloride 的口服生物利用度较差，需要通过前药 PAK4-IN-1 (HY-130628) 改善吸收和代谢稳定性。CZh226 hydrochloride 可用于研究结直肠癌和黑色素瘤。

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CZh226 hydrochloride

CZh226 hydrochloride Chemical Structure

CAS No. : 2231440-94-9

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CZh226 hydrochloride 相关抗体

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  • 生物活性

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生物活性

CZh226 hydrochloride is a potent and selective PAK4 inhibitor with an IC50 of 18 nM, and its selectivity for PAK1 is 346 times. The oral bioavailability of CZh226 hydrochloride is poor, and it requires the use of the prodrug PAK4-IN-1 (HY-130628) to improve absorption and metabolic stability. CZh226 hydrochloride can be used for research on colorectal cancer and melanoma[1].
IC50 & Target[1]

PAK4

18 nM (IC50)

分子量

448.35

Formula

C20H23Cl2N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CZh226 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

CZh2262231440-94-9CZh 226CZh-226PAKp21 activated kinasesPAK4 inhibitorProdrug strategyOral bioavailabilityPharmacokineticsStructure-based drug design (SBDD)HTRF assayRat plasma stabilityXenograft modelInhibitorinhibitorinhibit

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产品名称：
CZh226 hydrochloride
目录号：
HY-111103A
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