2. Neuronal Signaling
  3. Serotonin Transporter Dopamine Transporter
  4. D-473

D-473 是一种口服有效、具有血脑屏障穿透能力的再摄取抑制剂，且偏好血清素。D-473 可抑制血清素、多巴胺和去甲肾上腺素转运体，显著提升大鼠脑区内这三种神经递质的细胞外水平。D-473 具有明确的类抗抑郁活性，不引发运动激活。D-473 被广泛用于重性抑郁症的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

D-473

D-473 Chemical Structure

CAS No. : 1632000-05-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

D-473 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-473 is an orally active, blood-brain barrier penetrant and serotonin-preferring reuptake inhibitor. D-473 inhibits serotonin, dopamine and norepinephrine transporters, and significantly elevates the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits definite antidepressant-like activity without inducing motor activation. D-473 is widely used in studies related to major depressive disorder[1].

体外研究
(In Vitro)

D-473 抑制表达克隆人 hDAT、hSERT 和 hNET 的 HEK 293 细胞中的单胺摄取，对 hSERT 的效力最高 (Ki=9.18 nM)，其次是 hNET (Ki=39.7 nM) 和 hDAT (Ki=70.4 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-473 相关抗体:
体内研究
(In Vivo)

D-473 (5-50 mg/kg；口服；单次给药；5 分钟游泳试验前 1 小时) 在大鼠强迫游泳试验中可剂量依赖性地显著缩短不动时间[1]。
D-473 (25 mg/kg；口服；单次给药) 对大鼠的自发活动无显著影响[1]。
D-473 (10 mg/kg；腹腔注射；单次给药) 可显著升高大鼠内侧前额叶皮层 (mPFC) 和背外侧纹状体 (DLS) 中的细胞外多巴胺、5-羟色胺和去甲肾上腺素水平，同时降低上述脑区中多巴胺代谢物的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat with major depressive disorder (male, 200-225 g)[1]
Dosage: 5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg
Administration: p.o.; single dose; 1 hour prior to 5-minute swim test
Result: Produced no significant reduction in immobility time at 5 mg/kg.
Reduced immobility time significantly compared to vehicle at 10 mg/kg.
Reduced immobility time significantly compared to vehicle at 25 mg/kg.
Reduced immobility time significantly compared to vehicle at 50 mg/kg.
分子量

439.49

Formula

C26H27F2NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-473 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-4731632000-05-5D473D 473Serotonin TransporterDopamine Transporter5-HTTSERTSLC6A4DATSLC6A3hNEThDAThSERTmajor depressive disorderdopamine transporterhuman histamine H2 receptorsHEK 293 cellsnorepinephrine transporterserotonin transporterratInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
D-473
目录号：
HY-182247
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z