2. Others Apoptosis
  3. Insecticide Apoptosis
  4. D-Tetramethrin

D-Tetramethrin 是一种 I 型合成拟除虫菊酯类杀虫剂 (Insecticide) 和肝毒性诱导剂。D-Tetramethrin 会诱导斑马鱼肝脏产生氧化应激。D-Tetramethrin 会诱导凋亡 (Apoptosis)、炎症反应。D-Tetramethrin 会导致斑马鱼肝脏严重损伤。D-Tetramethrin 可用于肝毒性相关研究。

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D-Tetramethrin

D-Tetramethrin Chemical Structure

CAS No. : 1166-46-7

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D-Tetramethrin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-Tetramethrin is a type I synthetic pyrethroid insecticide and hepatotoxicity inducer. D-Tetramethrin induces oxidative stress in the liver of zebrafish. D-Tetramethrin induces Apoptosis and inflammatory responses. D-Tetramethrin causes severe liver damage in zebrafish. D-Tetramethrin can be used in studies related to hepatotoxicity[1].

体内研究
(In Vivo)

D-Tetramethrin (0.5-1.5 mg/L) 会在斑马鱼幼鱼中诱导剂量依赖性肝毒性，产生的效应包括肝脏体积减小、卵黄吸收障碍、肝脏组织病理学损伤、糖脂代谢紊乱、氧化应激、炎症反应以及肝细胞增殖受抑制[1]。
D-Tetramethrin (0.1-0.15 mg/L; 28 天) 会在成年斑马鱼中诱导剂量依赖性肝毒性，产生的效应包括肝脏组织病理学损伤、脂质与葡萄糖代谢紊乱以及代谢酶活性改变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic Tg(fabp10a: DsRed); wild-type AB (3 days post-fertilization)[1]
Dosage: 0.5 mg/L; 1 mg/L; 1.5 mg/L
Administration: waterborne exposure; daily;
Result: Reduced liver fluorescence area by 10.38% (0.5 mg/L), 7.62% (1 mg/L), and 13.75% (1.5 mg/L) relative to controls.
Increased yolk area by 22.63% (0.5 mg/L), 23.61% (1 mg/L), and 41.32% (1.5 mg/L) relative to controls.
Induced nuclear deformities, loose irregular intercellular gaps, vacuoles, cytoplasmic loss, and nuclear distortion in hepatocytes.
Increased lipid accumulation in a concentration-dependent manner.
Elevated total cholesterol (TC) and total triglycerides (TG) levels significantly across all doses.
Increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities significantly relative to controls.
Increased reactive oxygen species (ROS) levels in a concentration-dependent manner.
Elevated catalase (CAT) activity significantly across all doses.
Elevated malondialdehyde (MDA) content significantly across all doses.
Reduced superoxide dismutase (SOD) activity significantly at 1 mg/L and 1.5 mg/L.
Increased expression of apoptosis-related genes (casp-3, casp-6, casp-9, Bax, P53) significantly, while decreased Bcl-2 expression significantly.
Increased Bax/Bcl-2 ratio significantly.
Increased expression of inflammation-related gene TLR4 significantly, while decreased il-10 expression significantly at 1 mg/L and 1.5 mg/L.
Detected no liver-specific apoptosis via TUNEL staining.
Observed significantly fewer proliferating liver cells via PCNA staining.
Reduced expression of cell cycle-promoting genes (ccne1, ccnd1, cdk6) significantly at 1 mg/L and 1.5 mg/L.
Animal Model: wild-type AB[1]
Dosage: 0.1 mg/L; 0.125 mg/L; 0.15 mg/L
Administration: waterborne exposure; daily continuous; 28 days
Result: Induced nuclear deformities, loose irregular intercellular gaps, and vacuoles in hepatocytes.
Increased lipid droplet accumulation in liver tissue in a concentration-dependent manner.
Elevated low-density lipoprotein cholesterol (LDL-C) levels significantly across all doses.
Increased isocitrate dehydrogenase (cytoplasmic, ICDHc) and glucose-6-phosphate dehydrogenase (G6PDH) activities significantly across all doses.
Increased lactate dehydrogenase (LDH) activity significantly at 0.1 mg/L, while reduced it significantly at 0.125 mg/L and 0.15 mg/L.
Reduced glycogen content significantly.
分子量

331.41

Formula

C19H25NO4
CAS 号
中文名称

右旋胺菊酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-Tetramethrin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Tetramethrin1166-46-7右旋胺菊酯InsecticideApoptosiszebrafish embryosoxidative stresslipid metabolismzebrafish liverType I synthetic pyrethroid insecticidecell proliferationinflammationglycogen metabolismhepatotoxicityapoptosisInhibitorinhibitorinhibit

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