2. Epigenetics
  3. Epigenetic Reader Domain
  4. DC-peptoid-1

DC-peptoid-1 是一种针对磷酸化 Brd4 PDID 区域的特异性结合剂与交联剂，其对人源靶点的解离常数 (Kd) 约为 50-100 μM。DC-peptoid-1 仅能结合磷酸化的 PDID 而无法识别非磷酸化形式或其他区域 (如 Brd4 598-785)。DC-peptoid-1 在溶液及细胞裂解物中均能与目标蛋白发生有效的交联反应，并可通过固定化方式从复杂体系中成功捕获磷酸化 PDID，且不会与细菌来源的非磷酸化蛋白或其它非特异性磷蛋白结合。DC-peptoid-1 有潜力作为磷蛋白特异性抗体替代物，用于免疫亲和纯化等应用。

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Custom Peptide Synthesis

DC-peptoid-1

DC-peptoid-1 Chemical Structure

CAS No. : 1334159-03-3

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DC-peptoid-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC-peptoid-1 is a specific binder and crosslinker targeting the phosphorylated Brd4 PDID domain, with a dissociation constant (Kd) of approximately 50-100 μM for human-derived targets. DC-peptoid-1 only binds to phosphorylated PDID and fails to recognize the non-phosphorylated form or other domains (such as Brd4 598-785). DC-peptoid-1 effectively crosslinks with the target protein both in solution and cell lysates. It can successfully capture phosphorylated PDID from complex systems via immobilization, without binding to bacterial-derived non-phosphorylated proteins or other non-specific phosphoproteins. DC-peptoid-1 has the potential to serve as a phosphoprotein-specific antibody substitute for applications such as immunoaffinity purification[1].
体外研究
(In Vitro)

Soluble DC-peptoid-1 可与 Brd4 蛋白的磷酸化 PDID 结合，估算 K0 为 50-100 μM，且与未修饰的 PDID 结合能力极弱[1]。
Cys-DC-peptoid-1 可从 Sf9 细胞裂解物中选择性捕获 Brd4 蛋白的磷酸化 PDID 结构域，但不结合未修饰的 PDID，且对裂解物中的其他组分存在一定非特异性结合[1]。
BD-DC-peptoid-1 (生物素化的 DC-peptoid-1) (0.5 μM) 可在 2 mM NaIO4 存在下，与溶液中浓度为 0.5 μM 的磷酸化 Brd4 蛋白发生特异性交联[1]。
BD-DC-peptoid-1 (0.5 μM) 可在 2 mM NaIO4 存在下，与完整 Sf9 细胞裂解物中的磷酸化 Brd4 蛋白发生交联，但同时也会与裂解物中的其他蛋白发生非特异性交联[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DC-peptoid-1 相关抗体:
分子量

807.04

Formula

C39H70N10O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DC-peptoid-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC-peptoid-11334159-03-3Epigenetic Reader Domainphosphorylated PDIDagarose beadsnon-phosphorylated PDIDphosphoproteinsbacterial cell lysatesDOPABrd4 (598-785)Sf9 cell lysatesBrd4biotinInhibitorinhibitorinhibit

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