2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation Apoptosis NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Nuclear Hormone Receptor 4A/NR4A Pyroptosis Reactive Oxygen Species (ROS) PERK Caspase
  4. DdBIC

DdBIC 是一种焦亡 (Pyroptosis) 诱导剂。DdBIC 结合 Nur77 并使其转位至线粒体，激活 SDHA 耗竭琥珀酰辅酶 A，破坏血红素稳态、引发电子泄漏，诱导线粒体 ROS 生成。DdBIC 诱生的线粒体 ROS 氧化激活 OMA1，促使 OPA1 切割并释至细胞质，经 PERK 激活整合应激反应，最终活化颗粒酶 B (granzyme B) 切割 GSDMC。DdBIC 可用于研究黑色素瘤。

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DdBIC

DdBIC Chemical Structure

CAS No. : 3085711-53-8

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DdBIC 相关抗体

Top Publications Citing Use of Products

查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

查看所有亚型
Nur77/NR4A1 Nurr1/NR4A2

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma[1].

分子量

330.46

Formula

C20H30N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DdBIC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DdBIC3085711-53-8Nuclear Hormone Receptor 4A/NR4APyroptosisReactive Oxygen Species (ROS)PERKCaspaseNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseGSDMCNuclear receptor Nur77Heme homeostasisMitochondrial ROSIntegrated stress response (ISR)Granzyme BMelanomaInhibitorinhibitorinhibit

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