2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease PI3K/Akt/mTOR MAPK/ERK Pathway Apoptosis
  3. HSP Akt CDK Raf Apoptosis
  4. DDO-6600

DDO-6600 是一种共价 Hsp90 抑制剂。DDO-6600 破坏 Hsp90 与共伴侣蛋白 Cdc37 的相互作用，从而诱导激酶客户蛋白 (如 AKT、CDK4、c-Raf) 降解。DDO-6600 对多种癌细胞具有抑制活性。DDO-6600 抑制 HCT-116 细胞迁移与侵袭，并诱导细胞周期阻滞和凋亡 (apoptosis)。DDO-6600 显著抑制 HCT-116 移植瘤模型中的肿瘤生长。DDO-6600 可用于研究结直肠癌。

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DDO-6600

DDO-6600 Chemical Structure

CAS No. : 2640292-37-9

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DDO-6600 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Raf 亚型特异性产品:

查看所有亚型
B-Raf C-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer[1].

IC50 & Target[1]

HSP90

 

Akt

 

CDK4

 

C-Raf

 

分子量

428.53

Formula

C26H28N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDO-6600 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-66002640292-37-9DDO6600DDO 6600HSPAktCDKRafApoptosisHeat shock proteinsPKBProtein kinase BCyclin dependent kinaseRaf kinasesHsp90covalent inhibitorCys598Cdc37client protein degradationantitumor activityheat shock responseInhibitorinhibitorinhibit

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