2. Membrane Transporter/Ion Channel GPCR/G Protein Apoptosis
  3. Prostaglandin Receptor Na+/K+ ATPase Caspase Apoptosis
  4. Deacetyltanghinin

Deacetyltanghinin 是靶向 Na+/K+ ATPase 的选择性抑制剂，通过非共价结合发挥作用但具有强心脏毒性。Deacetyltanghinin 抑制 Na+/K+ ATPase 活性，诱导癌细胞发生 caspase 介导的凋亡 (apoptosis)，同时可影响兔心脏中 TXA2-PGI2 平衡。Deacetyltanghinin 具有显著的抗癌活性，主要应用于乳腺癌、肺癌等恶性肿瘤的靶向研究领域，特别是心脏毒性的调控机制等。

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Deacetyltanghinin

Deacetyltanghinin Chemical Structure

CAS No. : 4589-95-1

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Deacetyltanghinin 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Deacetyltanghinin is a selective inhibitor targeting Na+/K+ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na+/K+ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity[1][2].

IC50 & Target

TXA2

 

分子量

548.66

Formula

C30H44O9
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Deacetyltanghinin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deacetyltanghinin4589-95-1Prostaglandin ReceptorNa+/K+ ATPaseCaspaseApoptosisSodium potassium pumpInhibitorinhibitorinhibit

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