2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite Drug Metabolite
  4. Decarbamoylsaxitoxin

Decarbamoylsaxitoxin  (Synonyms: DcSTX; DecarbamoylSTX)

目录号: HY-135000
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Decarbamoylsaxitoxin 是一种钠通道抑制剂，可阻止钠离子通过可兴奋神经和骨骼肌细胞膜内流，从而阻断动作电位的形成。Decarbamoylsaxitoxin 是石房蛤毒素的酸性水解产物，对小鼠产生的毒性作用与石房蛤毒素完全一致。Decarbamoylsaxitoxin 可通过阻断 Na+ channels 抑制藜芦定和哇巴因诱导的小鼠神经母细胞瘤细胞肿胀与裂解。Decarbamoylsaxitoxin 可用于麻痹性贝类中毒的相关研究[1][2]。

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Decarbamoylsaxitoxin

Decarbamoylsaxitoxin Chemical Structure

CAS No. : 58911-04-9

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Decarbamoylsaxitoxin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na+ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning[1][2].

体外研究
(In Vitro)

Decarbamoylsaxitoxin (200-1000 pg/well, 3 nM to 300 μM; 8-24 hr) 可抑制哇巴因/藜芦定诱导的小鼠神经母细胞瘤细胞 (ATCC no. CCL 131) 裂解，与美国 FDA 石房蛤毒素标准品相比，其平均相对毒性为 42.6%[2]。
Decarbamoylsaxitoxin (110 μg/mL; 5 min boiled in 0.1 N or 1.0 N HCl) 在 0.1 N 或 1.0 N HCl 中煮沸 5 分钟后仍保持稳定 (毒性未发生改变)，该结果通过小鼠神经母细胞瘤细胞实验测得[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Decarbamoylsaxitoxin 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: mouse neuroblastoma cells (ATCC no. CCL 131)
Concentration: 200-1000 pg/well; 3 nM to 300 μM (tested immediately after opening sealed ampoules)
Incubation Time: 8-24 hr
Result: Exhibited a dose-response profile in the neuroblastoma cell bioassay, with mean relative toxicity of 42.6% compared to US FDA saxitoxin standard (set at 100%).
Showed overlapping dose-response profile shape with GTX II/III-1.
Increased absorbance values of adherent stained cells with higher decarbamoylsaxitoxin concentrations.
分子量

256.26

Formula

C9H16N6O3
CAS 号
结构分类
初始来源

Gonyaulax catenella
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Decarbamoylsaxitoxin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decarbamoylsaxitoxin58911-04-9DcSTX DecarbamoylSTXEndogenous MetaboliteDrug Metabolitesaxitoxin receptorsodium channelsodium ionsouabainparalytic shellfish poisoningaction potentialveratridinenerve membranesmouse neuroblastoma cellskeletal muscle membranesInhibitorinhibitorinhibit

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