Deldeprevir sodium  (Synonyms: ACH-2684 sodium; Neceprevir sodium)

Deldeprevir (ACH-2684; Neceprevir) sodium is a HCV NS3/4A protease inhibitor and resistance inhibitor. Deldeprevir sodium exhibits activity against wild-type genotype 1a and 1b HCV, including mutant strains resistant to other NS3 protease inhibitors. Deldeprevir sodium blocks the emergence of HCV mutant strains resistant to ACH-3422 in vitro, with enhanced efficacy when used in triple combination with ACH-3422 and ACH-3102 (HY-124182). Deldeprevir sodium shows additive antiviral potency when combined with ACH-3422, and exerts antiviral activity against HCV replicons carrying ACH-3102. Deldeprevir sodium is applicable to research related to hepatitis C^[1][2][3].

Deldeprevir sodium (3 d) 对基因 1a 型和 1b 型 HCV 复制子的体外效力高于 BMS-032，且其与 ACH-3102 联合使用可减少这些复制子细胞系中耐药变异株的出现^[1]。
Deldeprevir sodium (3 d) 对基因 1a 型和 1b 型 HCV 复制子的体外效力高于参照 NS3 蛋白酶抑制剂，且与 HCV NS5A 抑制剂联用时表现出相加或协同的抗病毒效力，同时可减少耐药变异体的出现^[2]。
Deldeprevir sodium 与 NS5B 核苷类抑制剂 ACH-3422 联用，或与 ACH-3422 及 NS5A 抑制剂 ACH-3102 三联使用，可增强抗病毒活性并在体外阻断 ACH-3422 耐药性 HCV 复制子的出现^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

933.07

C₄₅H₅₅F₂N₆NaO₈S₂

1298053-61-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhao Y, et al. In VitroStudies Demonstrate a High Probability of Curing Genotype-1 Hepatitis C Patients with Combination of a Novel NS3 Protease Inhibitor ACH-2684 and a Novel NS5A Inhibitor ACH-3102: 1886[J]. Hepatology, 2012, 56: 1071A-1072A.

  [2]. Baglino S L, et al. Pegylated Interferons Lambda-1a and Alfa-2a Display Different Gene Induction and Cytokine Release Profiles in Both Human Hepatocytes and Peripheral Blood Mononuclear Cells: 1885[J]. Hepatology, 2012, 56: 1071A.

  [3]. Zhou X J, et al. Pharmacokinetics and Drug-Drug Interaction between Samatasvir, an NS5A Inhibitor, and Co-administered Simeprevir, an NS3/4A Protease Inhibitor, and Low Dose Ritonavir-Boosted TMC647055, a Non-Nucleoside NS5B Inhibitor, in Healthy Volunteers and HCV-Infected Subjects: 1987[J]. Hepatology, 2014, 60: 1167A-1168A.