2. Others Neuronal Signaling GPCR/G Protein
  3. Dopamine Receptor 5-HT Receptor Isotope-Labeled Compounds
  4. Desmethyl cariprazine-d8

Desmethyl cariprazine-d8 是氘代标记的 Desmethyl cariprazine (HY-100656)。Desmethyl cariprazine 是卡利拉嗪的一种主要活性代谢产物，对人多巴胺受体和 5-羟色胺受体具有活性，人 D2 受体 pEC50 = 8.90，D3 受体 pEC50 = 8.09，5-HT1A 受体 pEC50 = 6.28。Desmethyl cariprazine 可抑制毛喉素诱导的 D2、D3 和 5-HT1A 受体的 cAMP 生成，并抑制 5-羟色胺诱导的 5-HT2B 受体的 Ca2+ 释放。Desmethyl cariprazine 可用于精神分裂症、双相情感障碍Ⅰ型、双相情感障碍的相关研究。

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Desmethyl cariprazine-d<sub>8</sub>

Desmethyl cariprazine-d8 Chemical Structure

CAS No. : 1308278-85-4

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1 mg ￥10840
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Other Forms of Desmethyl cariprazine-d8:

Desmethyl cariprazine-d8 相关抗体

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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  • 生物活性

  • 纯度 & 产品资料

生物活性

Desmethyl cariprazine-d8 is the deuterium labeled Desmethyl cariprazine (HY-100656). Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC50 of 8.90 at human D2 receptors, a pEC50 of 8.09 at D3 receptors, and a pEC50 of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca2+ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Desmethyl cariprazine-d8 相关抗体:
分子量

421.43

Formula

C20H22D8Cl2N4O
CAS 号
非标记 CAS
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.90%

COA (267 KB)

产品使用指南 (1538 KB)

Desmethyl cariprazine-d8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desmethyl cariprazine-d81308278-85-4Dopamine Receptor5-HT ReceptorIsotope-Labeled CompoundsSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
HY-100656AS
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