2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DHPS-IN-3

DHPS-IN-3 (Compound 26d) 是一种 NAD 竞争性的 DHPS 抑制剂，在 14 μM NAD 条件下的 IC50 为 0.0092 μM，在 250 μM NAD 条件下的 IC50 为 0.069 μM。DHPS-IN-3 可用于肿瘤研究。

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DHPS-IN-3

DHPS-IN-3 Chemical Structure

CAS No. : 2470012-40-7

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DHPS-IN-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC50 of 0.0092 μM at 14 μM NAD and an IC50 of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research[1].

体外研究
(In Vitro)

DHPS-IN-3 可强效抑制 DHPS，在 14 μM NAD 条件下的 IC50 为 0.0092 μM，呈现 NAD 竞争性抑制特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHPS-IN-3 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Vdss CLtotal Cmax MRT F
Mice[1] 0.1 mg/kg i.v. 8491 mL/kg 8965 mL/h/kg / / /
Mice[1] 1 mg/kg p.o. / / 4.8 ng/mL 2.46 h 11.7 %
分子量

329.46

Formula

C18H23N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHPS-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHPS-IN-32470012-40-7DNA/RNA Synthesishydrophobic pocketDeoxyhypusine synthaseLys287NADallosteric siteDHPShydrogen bondsallosteric pocketInhibitorinhibitorinhibit

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产品名称：
DHPS-IN-3
目录号：
HY-182529
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