2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Caspase Reactive Oxygen Species (ROS) Apoptosis
  4. Dicatenarin

Dicatenarin 是一种 caspase‑3 激活剂，对人类癌细胞具有生长抑制活性。Dicatenarin 可提升 caspase‑3 活性，诱导细胞内 ROS 的产生，并激活线粒体介导的凋亡 (apoptosis) 通路。Dicatenarin 对一系列人类癌细胞系均有生长抑制作用。Dicatenarin 可用于胰腺癌、肺癌、结肠癌、乳腺癌、前列腺癌及卵巢癌的相关研究.

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Dicatenarin

Dicatenarin Chemical Structure

CAS No. : 1065-08-3

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Dicatenarin 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer[1][2].

IC50 & Target[1]

Caspase-3

 

体外研究
(In Vitro)

Dicatenarin (1-100 µg/mL; 48 h) 可在体外强效抑制人肺癌 (A549)、胰腺癌 (MIA PaCa-2)、结肠癌 (HCT-116)、乳腺癌 (T47D)、前列腺癌 (PC-3) 和卵巢癌 (OVCAR-3) 细胞系的生长，其中对 MIA PaCa-2 细胞的最低 IC50 为 12 µg/mL[1][2]。
Dicatenarin (5-20 µg/mL; 48 h) 可诱导人胰腺癌 (MIA PaCa-2) 细胞呈浓度依赖性的凋亡核形态学改变[1]。
Dicatenarin (20 µg/mL; 48 h) 可诱导人胰腺癌 (MIA PaCa-2) 细胞发生早期和晚期凋亡[1]。
Dicatenarin (5-20 µg/mL; 48 h) 可诱导人胰腺癌 (MIA PaCa-2) 细胞呈浓度依赖性的细胞内 ROS 生成[1]。
Dicatenarin (5-20 µg/mL; 48 h) 可诱导人胰腺癌 (MIA PaCa-2) 细胞的线粒体跨膜电位呈浓度依赖性丧失[1]。
Dicatenarin (5-20 µg/mL; 48 h) 可诱导人胰腺癌细胞 (MIA PaCa-2) 中细胞色素 c 从线粒体向胞质溶胶呈浓度依赖性释放[1]。
Dicatenarin (5-20 µg/mL; 48 h) 可在体外诱导人胰腺癌 (MIA PaCa-2) 细胞中 caspase-3 呈浓度依赖性激活[1]。
Dicatenarin (5-20 µg/mL; 7 days) 可强效抑制人胰腺癌细胞 (MIA PaCa-2) 的克隆形成存活能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dicatenarin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, MIA PaCa-2, HCT-116, T47D, PC-3, OVCAR-3
Concentration: 1, 10, 30, 50, 100 µg/mL
Incubation Time: 48 h
Result: Exhibited cytotoxicity against all tested cell lines, with IC50 values of 23 µg/mL (A549), 12 µg/mL (MIA PaCa-2), 17 µg/mL (HCT-116), 29 µg/mL (T47D), 35 µg/mL (PC-3), and 26 µg/mL (OVCAR-3).

Apoptosis Analysis[1]

Cell Line: MIA PaCa-2
Concentration: 20 µg/mL
Incubation Time: 48 h
Result: Resulted in significant phosphatidylserine externalization (early apoptosis) and late-stage apoptotic/necrotic PI-positive staining, with a higher proportion of annexin V-positive cells compared to skyrin treatment.

Immunofluorescence[1]

Cell Line: MIA PaCa-2
Concentration: 5, 10, 20 µg/mL
Incubation Time: 48 h
Result: Induced concentration-dependent release of cytochrome c from mitochondria into the cytosol.
Showed minimal release at 5 µg/mL, moderate release at 10 µg/mL, prominent, diffuse cytosolic cytochrome c staining at 20 µg/mL, indicating complete mitochondrial outer membrane permeabilization.

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2
Concentration: 5, 10, 20 µg/mL
Incubation Time: 7 days
Result: Caused concentration-dependent inhibition of colony formation.
Reduced colony number to ~460 (from ~550 in controls) at 5 µg/mL, to ~210 at 10 µg/mL, to ~50 at 20 µg/mL, representing a 91% reduction in colony formation at the highest concentration.
分子量

570.46

Formula

C30H18O12
CAS 号
结构分类
初始来源

Penicillium pinophilum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dicatenarin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicatenarin1065-08-3CaspaseReactive Oxygen Species (ROS)ApoptosisNCI60/ATCC panelMIA PaCa-2caspase-3A549mitochondrial-mediated apoptotic pathwayshuman pancreatic cancer cellsmitochondrial transmembrane potentialhuman cancer cellsHCT-116reactive oxygen speciesInhibitorinhibitorinhibit

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