2. Others Neuronal Signaling GPCR/G Protein
  3. Dopamine Receptor 5-HT Receptor Isotope-Labeled Compounds
  4. Didesmethyl cariprazine-d8

Didesmethyl cariprazine-d8 是氘代标记的 Didesmethyl cariprazine (HY-100658)。Didesmethyl cariprazine 是口服活性、血脑屏障透过性的 Cariprazine (HY-14763) 代谢物。Didesmethyl cariprazine 是 D2 和 D3 受体的部分激动剂、5-HT1A 受体的完全激动剂、人 5-HT2B 受体的拮抗剂 (Ki： 1.41 nM (人 D2L))、0.056 nM (人 D3)、1.7 nM (人 5-HT1A)、0.52 nM (人 5-HT2B))。Didesmethyl cariprazine 剂量依赖性地抑制大鼠中脑多巴胺能神经元的自发活动。

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Didesmethyl cariprazine-d<sub>8</sub>

Didesmethyl cariprazine-d8 Chemical Structure

CAS No. : 1308279-08-4

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1 mg ￥10840
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Other Forms of Didesmethyl cariprazine-d8:

Didesmethyl cariprazine-d8 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Didesmethyl cariprazine-d8 is the deuterium labeled Didesmethyl cariprazine (HY-100658). Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine (HY-14763). Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (Ki: 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons.

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2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Didesmethyl cariprazine-d8 相关抗体:
分子量

407.41

Formula

C19H20D8Cl2N4O
CAS 号
非标记 CAS
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.40%

COA (265 KB)

产品使用指南 (1538 KB)
参考文献

Didesmethyl cariprazine-d8 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Didesmethyl cariprazine-d81308279-08-4Dopamine Receptor5-HT ReceptorIsotope-Labeled CompoundsSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
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