2. Others Neuronal Signaling
  3. Insecticide Cholinesterase (ChE)
  4. Dimefluthrin

Dimefluthrin 是一种杀虫剂。Dimefluthrin 对入侵红火蚁工蚁具有接触毒性。Dimefluthrin 可在入侵红火蚁工蚁间发生水平传递，导致接受毒物的工蚁出现继发性死亡。Dimefluthrin 是一种神经发育毒物，可降低乙酰胆碱酯酶 (acetylcholinesterase) 活性，损害神经递质。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Dimefluthrin

Dimefluthrin Chemical Structure

CAS No. : 271241-14-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Dimefluthrin 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimefluthrin is an insecticide. Dimefluthrin exhibits contact toxicity against large red imported fire ant workers. Dimefluthrin undergoes horizontal transfer among red imported fire ant workers, causing secondary mortality in recipient workers. Dimefluthrin is a neurodevelopmental toxicant, which can reduces acetylcholinesterase activity, impairing neurotransmitter[1][2].

IC50 & Target[1]

AChE

 

体外研究
(In Vitro)

Dimefluthrin (0.325-12 μg/mL; 24 h) 可高效灭杀大型红火蚁工蚁，其 LD50 为 1.57 ng/ant[2]。
Dimefluthrin 可快速击倒大型红火蚁工蚁，其 KT50 值在 0.5 至 5 μg/mL 之间[2]。
Dimefluthrin (30-60 μg/mL) 溶液可在红火蚁 (Solenopsis invicta) 工蚁之间有效水平传递；在 60 μg mL-1 浓度下，可使二级受药蚁在 24 h 内死亡率 >98%，三级受药蚁在 48 h 内死亡率最高达 99.33%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dimefluthrin 相关抗体:
体内研究
(In Vivo)

Dimefluthrin (0.2-0.8 μg/mL; 72 h) 会在斑马鱼幼鱼中诱导浓度依赖性的神经发育损伤、血管功能障碍、神经传递紊乱以及运动行为抑制；在低至 0.2 μg/mL 的剂量下即可观察到显著效应，在最高测试剂量 0.8 μg/mL 下可几乎完全抑制 CNS 轴突束的生长，且这些运动效应可被 Bromocriptine (HY-12705) 逆转[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Danio rerio larvae (5 days post-fertilization larvae)[1]
Dosage: 0.2, 0.4, 0.8 μg/mL
Administration: waterborne; continuous; 72 h (solution replacement every 24 h)
Result: Caused concentration-dependent inhibition of olfactory bulb, telencephalon, mesencephalon, medulla oblongata, optic parietal region, and hindbrain neuron development.
Reduced relative length of CNS axon tracts by ~50% at 0.4 μg/mL (P < 0.01) and ~90% at 0.8 μg/mL (P < 0.01).
Widened hindbone spacing in a concentration-dependent manner, with a ~3-fold increase at 0.8 μg/mL (P < 0.01).
Reduced relative fluorescence intensity of overall brain vasculature by ~20% at 0.2 μg/mL (P < 0.05), ~50% at 0.4 μg/mL (P < 0.01), and ~80% at 0.8 μg/mL (P < 0.01).
Widened intersegmental vessel spacing by ~70% at 0.8 μg/mL (P < 0.01), with no significant changes at 0.2 or 0.4 μg/mL.
Reduced relative fluorescence intensity of cerebral veins by ~50% at 0.4 μg/mL (P < 0.01) and ~70% at 0.8 μg/mL (P < 0.01), with no significant change at 0.2 μg/mL.
Caused disorganized, sparse brain cell distribution with vacuolization, blurred brain structure borders, and tail muscle cell vacuolization at all tested doses.
Induced coin-shaped skeletal fiber arrangements in the notochord at 0.8 μg/mL.
Decreased acetylcholinesterase activity in a concentration-dependent manner, with significant decreases at all tested doses (P < 0.01).
Dysregulated expression of neurodevelopment-related genes, including upregulation of elavl3 and downregulation of syn2a, dat, mao, and dr1 in a concentration-dependent manner.
Upregulated comt and th gene expression by ~2.2-fold and ~2.8-fold, respectively, at 0.8 μg/mL (P < 0.01).
Induced concentration-dependent suppression of locomotor activity, with total swimming distance reduced by ~30% at 0.2 μg/mL, ~50% at 0.4 μg/mL (P < 0.01), and ~80% at 0.8 μg/mL (P < 0.01).
Reduced swimming speed and acceleration in a concentration-dependent manner.
Restored total swimming distance, speed, and acceleration to levels near those of untreated controls when co-exposed with Bromocriptine for dimefluthrin-induced locomotor suppression.
分子量

374.38

Formula

C19H22F4O3
CAS 号
中文名称

四氟甲醚菊酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimefluthrin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimefluthrin271241-14-6四氟甲醚菊酯InsecticideCholinesterase (ChE)blood-brain barrierperipheral nervezebrafish larvaelarge red imported fire ant workerssyn2aSolenopsis invictaneurodevelopmental toxicantimmunocompromised childrenolfactory bulbacetylcholinesteraseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Dimefluthrin
目录号：
HY-135450
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z