2. Immunology/Inflammation
  3. Kallikrein
  4. DKFZ-633

DKFZ-633 是一种强效的 KLK6 抑制剂和 KLK6 特异性探针，对人源 KLK6 的 IC50=250 nM。DKFZ-633 特异性地共价标记活性状态的 KLK6，能从细胞条件培养基中成功下拉捕获内源性活性 KLK6。DKFZ-633 是研究头颈癌中 KLK6 功能及其调控机制的重要工具。

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DKFZ-633

DKFZ-633 Chemical Structure

CAS No. : 2244425-14-5

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DKFZ-633 相关抗体

Top Publications Citing Use of Products

查看 Kallikrein 亚型特异性产品:

查看所有亚型
KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DKFZ-633 is a potent KLK6 inhibitor and KLK6-specific probe with an IC50 of 250 nM against human KLK6. DKFZ-633 covalently labels active KLK6 in a specific manner, and successfully pulls down and captures endogenous active KLK6 from cell-conditioned media. DKFZ-633 serves as a critical tool for investigating the function of KLK6 and its regulatory mechanisms in head and neck cancer[1].

体外研究
(In Vitro)

DKFZ-633 (compound 44) (0.25 μM; 30 min) 可抑制重组型三重突变人源 KLK6，在室温下预孵育 30 min 后其 IC50 为 0.25 μM[1]。
DKFZ-633 (12-25 μM; 1 h；室温) 以剂量依赖的方式从 FaDu 细胞条件培养基中下拉出具有活性的内源性人 KLK6[1]。
DKFZ-633 (50 μM; 1 h；室温) 可从多种人类癌细胞系的条件培养基中下拉出具有活性的内源性人 KLK6，包括两种细胞依赖性糖型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DKFZ-633 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: FaDu head and neck squamous cell carcinoma cells
Concentration: 100, 300, 500 nM
Incubation Time: 48 h (daily treatment)
Result: Increased BrdU-positive FaDu cells in a dose-dependent manner: ~45% (100 nM), ~50% (300 nM), ~60% (500 nM), compared to ~45% in vehicle control.
Induced a dose-dependent phenotypic change in FaDu cells, mimicking the effect of KLK6 shRNA silencing.
分子量

440.50

Formula

C26H24N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DKFZ-633 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DKFZ-6332244425-14-5DKFZ633DKFZ 633KallikreinKLKKallikrein-related peptidaseFaDu cellkallikrein-related peptidase 6head and neck cancerhuman cancer cell linesKLK6Inhibitorinhibitorinhibit

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产品名称：
DKFZ-633
目录号：
HY-124610
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