2. MAPK/ERK Pathway
  3. MAP3K
  4. DLK-IN-2

DLK-IN-2 是 DLK 的选择性抑制剂与神经保护剂。DLK-IN-2 对 CYPs 3A4、2D6 和 2C9 无显著抑制作用。DLK-IN-2 可抑制 DLK 的急性轴突棕榈酰化，阻断依赖 DLK 的促退行性轴突-胞体逆向信号传导，并抑制 c-Jun 磷酸化。DLK-IN-2 可用于神经退行性疾病的机制研究。

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DLK-IN-2

DLK-IN-2 Chemical Structure

CAS No. : 883012-32-6

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DLK-IN-2 相关抗体

Top Publications Citing Use of Products

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1 MAP3K12/DLK/Pref-1 NIK/MAP3K14

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DLK-IN-2 is a selective inhibitor of DLK and neuroprotective agent. DLK-IN-2 shows no significant inhibition against CYPs 3A4, 2D6 and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent pro-degenerative axon-to-soma retrograde signaling and suppresses c-Jun phosphorylation. DLK-IN-2 can be used for the mechanistic study of neurodegenerative diseases[1].

IC50 & Target[1]

MAP3K12/DLK

 

体外研究
(In Vitro)

DLK-IN-2 (compound 13) (10 μM; 1 h pre-incubation, 2.5 h post-deprivation) 可显著抑制原代胚胎第 16 天大鼠 DRG 神经元中由营养因子剥夺诱导的 c-Jun 磷酸化[1]。
DLK-IN-2 (10 μM; 1 h pre-incubation, 45 h post-deprivation) 可显著保护胚胎第 16 天大鼠原代 DRG 神经元免受营养因子剥夺诱导的神经退行性变[1]。
DLK-IN-2 (10 μM; 4 h post-injury) 可短暂减轻原代胚胎第 16 天大鼠 DRG 神经元斑点培养物中急性轴突切断诱导的沃勒变性，但在损伤后 6 h 对轴突无保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DLK-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: Embryonic rat DRG neurons
Concentration: 10 μM
Incubation Time: 2.5 h (p-c-Jun); 4 h (NMNAT2, STMN2)
Result: Significantly reduced TD-induced c-Jun phosphorylation; did not stabilize NMNAT2 or STMN2.
分子量

444.97

Formula

C23H25ClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DLK-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DLK-IN-2883012-32-6MAP3KMAP kinase kinase kinase, MEKK, MAPKKKneurodegenerationaxonsmouse liver microsomesWallerian degenerationrat DRG neuronsDLKtrophic factor deprivationCYP450 enzymesvincristineneuronal cell bodiesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181662
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