2. Metabolic Enzyme/Protease
  3. Liposome
  4. DMPG

DMPG  (Synonyms: L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol)

目录号: HY-177191
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DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) 是一种磷脂，可用于合成脂质体或凝胶等制剂。DMPG 可用于药物递送的研究。

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DMPG

DMPG Chemical Structure

CAS No. : 185463-22-3

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Other Forms of DMPG:

DMPG 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) is a phospholipid that can be used for preparing formulations such as liposomes or gels. DMPG can be used in the research of drug delivery[1][2].

体外研究
(In Vitro)

DMPG 已被证实具有较宽的凝胶-流体转变区间，范围为 18 至 35 ℃[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DMPG 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Tmax Cmax AUC0-t MRT0-t
Mice[1] 20 mg/kg i.p. 1.87 ± 0.28 h 0.73 ± 0.34 h 261.9 ± 146.2 ng/mL 188.5 ± 119.3 ng·h/mL 1.65 ± 0.37 h
体内研究
(In Vivo)

DMPG (1.6-4.8 mg/kg；静脉注射；单剂量) 表现出制剂依赖性消除动力学：当作为两性霉素 B 磷脂复合物混悬液给药时，其半衰期更长 (4.6-8.1 h)，而单独给药时半衰期为 1.1-2.3 h；且在所有测试剂量下，Cmax 和 AUC0-t 呈剂量比例升高，同时在肺、肝、脾和肾脏中存在优先组织蓄积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crl:CD(SD) rats (225 ± 25 g, equal gender distribution, SPF grade)[1]
Dosage: 1.6 mg/kg, 3.2 mg/kg, 4.8 mg/kg
Administration: i.v.; single dose
Result: Exhibited elimination half-life values of 1.081 ± 0.277 h (1.6 mg/kg), 1.448 ± 0.287 h (3.2 mg/kg), 2.348 ± 0.325 h (4.8 mg/kg) when administered alone.
Showed maximum plasma concentration (Cmax) values of 10168.9 ± 2262.1 μg/L (1.6 mg/kg), 14904.4 ± 1706.4 μg/L (3.2 mg/kg), 78723.6 ± 56402.7 μg/L (4.8 mg/kg) when administered alone.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 3586.7 ± 721.7 μg/L·h (1.6 mg/kg), 4913.1 ± 632.8 μg/L·h (3.2 mg/kg), 23248.4 ± 15236.8 μg/L·h (4.8 mg/kg) when administered alone.
Exhibited elimination half-life values of 8.078 ± 6.523 h (1.6 mg/kg), 4.561 ± 3.542 h (3.2 mg/kg), 4.645 ± 3.531 h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Showed maximum plasma concentration (Cmax) values of 3922.9 ± 2039.2 μg/L (1.6 mg/kg), 8201.2 ± 2227.9 μg/L (3.2 mg/kg), 10523.3 ± 2049.1 μg/L (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 1568.3 ± 695.5 μg/L·h (1.6 mg/kg), 3198.9 ± 695.5 μg/L·h (3.2 mg/kg), 5096.1 ± 1166.1 μg/L·h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Rapidly distributed to most tissues, with highest concentrations in lungs, liver, spleen, and kidneys; minimal levels detected in brain, heart, small intestine, muscle, testes, ovaries, uterus, adipose tissue, and stomach.
分子量

666.86

Formula

C34H67O10P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DMPG 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMPG185463-22-3L-α-Dimyristoylphosphatidylglycerol 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerolLiposomegelliverratsamphotericin B phospholipidInhibitorinhibitorinhibit

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