2. Metabolic Enzyme/Protease
  3. Liposome
  4. DSPE-PEG5000-GALA

DSPE-PEG5000-GALA 是一种 PEG 化合物，由 DSPE 和肺内皮靶向肽 GALA (HY-P5423) 组成。GALA 是一种由 30 个氨基酸组成的 pH 响应型两亲肽，是肺内皮靶向配体。GALA 能在 pH 5.0 的酸性环境下发生从无规卷曲到 α-螺旋的构象转变，从而诱导内体膜去稳定化和融合。GALA 介导修饰后的脂质体通过网格蛋白依赖的内吞及转胞吞作用穿越肺内皮细胞，并在静脉注射后特异性蓄积于肺部。DSPE-PEG5000-GALA 可用于药物递送。

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DSPE-PEG5000-GALA

DSPE-PEG5000-GALA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Other Forms of DSPE-PEG5000-GALA:

DSPE-PEG5000-GALA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DSPE-PEG5000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG5000-GALA can be used for drug delivery[1].

体外研究
(In Vitro)

用于制备纳米颗粒的脂质是一类兼具结构多样性、生物相容性与功能可调性的两亲性生物分子，其作为纳米递送系统的核心骨架，不仅通过自组装形成脂质双层或固体基质以包封亲脂性或亲水性药物，还可依据制剂需求细分为结构性脂质 (如磷脂、三酰甘油)、功能型脂质 (如可电离阳离子脂质用于核酸缩合与内体逃逸) 以及空间稳定型脂质 (如 PEG 化脂质)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DSPE-PEG5000-GALA 相关抗体:
分子量

9120 (Average)

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DSPE-PEG5000-GALA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSPE-PEG5000-GALALiposomeLipid-modified Targeted PeptideInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-182098C
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