2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Lipoxygenase Prostaglandin Receptor
  4. E 3040

E 3040 是一种具有口服活性的 5-脂氧合酶 (5-lipoxygenase) 和血栓素合酶 (thromboxane synthase) 的双重抑制剂。E 3040 具有抗炎作用。

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E 3040

E 3040 Chemical Structure

CAS No. : 145096-30-6

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E 3040 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect[1].

IC50 & Target[1]

5-Lipoxygenase

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RBL-1 IC50
0.23 μM
Compound: 26a
Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells
Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells
[PMID: 7932529]
体内研究
(In Vivo)

E 3040 (30-100 mg/kg，口服) 在经 LPS (HY-D1056) 处理的大鼠中显示出抗炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056)-treated rats[1]
Dosage: 30 and 100 mg/kg
Administration: Orally administration
Result: Inhibited the increase in vascular permeability.
Inhibited the production of leukotriene B(4) and thromboxane B(2).
Increased the production of prostaglandin E(2).
分子量

299.39

Formula

C16H17N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E 3040 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E 3040145096-30-6E3040E-3040LipoxygenaseProstaglandin ReceptorLOX5-lipoxygenasethromboxane synthaseLPSanti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
E 3040
目录号：
HY-105193
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