2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. EG01449 Free acid

EG01449 Free acid 是一种喹啉类神经纤毛蛋白-1 (NRP1) 拮抗剂，其 Kd 值为 0.6 µM。EG01449 Free acid 可竞争性抑制 VEGFA 与 NRP1 的结合，IC50 值为 362 nM。EG01449 Free acid 通过抑制 NRP1-依赖性信号传导和减少感觉神经元中的钠电流，防止 VEGFA 引起的疼痛。EG01449 Free acid 可以穿过血脑屏障，使中枢神经系统内可以进行靶向作用。EG01449 Free acid 可用于研究疼痛。

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EG01449 Free acid

EG01449 Free acid Chemical Structure

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EG01449 Free acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EG01449 Free acid is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM. EG01449 Free acid competitively inhibits the binding of VEGFA to NRP1 with an IC50 of 362 nM. EG01449 Free acid prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 Free acid can be used for the research of nociceptive pain[1].

分子量

686.83

Formula

C28H34N10O5S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EG01449 Free acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EG01449EG 01449EG-01449VEGFRVascular endothelial growth factor receptorneuropilinantinociceptivechronic painVEGF NRP1Inhibitorinhibitorinhibit

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产品名称：
EG01449 Free acid
目录号：
HY-179350
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