2. Apoptosis PI3K/Akt/mTOR JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Apoptosis PI3K mTOR EGFR
  4. EGFR WT/T790M-IN-4

EGFR WT/T790M-IN-4 是一种抗癌剂。EGFR WT/T790M-IN-4 是 EGFRWT 和 EGFRT790M 的抑制剂，IC50 为 0.133 μM 和 0.043 μM。EGFR WT/T790M-IN-4 也可抑制 PI3K 和 mTOR 激酶，其 IC50 值分别为 0.22 μM 和 0.35 μM。EGFR WT/T790M-IN-4 能诱导癌细胞周期阻滞和凋亡 (apoptosis)，抑制癌细胞增殖。EGFR WT/T790M-IN-4 可用于前列腺癌、结肠癌、乳腺癌的相关研究。

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EGFR WT/T790M-IN-4

EGFR WT/T790M-IN-4 Chemical Structure

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EGFR WT/T790M-IN-4 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR WT/T790M-IN-4 is an anticancer agent. EGFR WT/T790M-IN-4 acts as an inhibitor of EGFRWT and EGFRT790M , with an IC50 of 0.133 μM and 0.043 μM, respectively. EGFR WT/T790M-IN-4 also inhibits PI3K and mTOR kinases, with IC50 values of 0.22 μM and 0.35 μM, respectively. EGFR WT/T790M-IN-4 induces cell cycle arrest and apoptosis in cancer cells, and inhibits cancer cell proliferation. EGFR WT/T790M-IN-4 can be used in research related to prostate cancer, colon cancer and breast cancer[1].

体外研究
(In Vitro)

EGFR WT/T790M-IN-4 (Compound 5d) 对 PC-3、Caco-2 和 MDA-231 癌细胞系表现出细胞毒活性，对应的 IC50 值分别为 9.46 μM、7.45 μM 和 5.92 μM[1]。
EGFR WT/T790M-IN-4 (5.92 μM) 可诱导 MDA-231 乳腺癌细胞发生 G1/S 期细胞周期阻滞和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR WT/T790M-IN-4 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-231
Concentration: 5.92 μM
Incubation Time: /
Result: Induced cell cycle arrest at the G1/S phase, with G0/G1 phase cells increasing to 59.15%, S phase to 39.52%, and G2/M phase decreasing to 1.33%.
分子量

543.01

Formula

C30H27ClN4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR WT/T790M-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR WT/T790M-IN-4ApoptosisPI3KmTOREGFRPhosphoinositide 3-kinaseMammalian target of RapamycinEpidermal growth factor receptorErbB-1HER1epidermal growth factor receptorCaco-2prostate cancercolon cancerMDA-231PC-3breast cancerInhibitorinhibitorinhibit

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