2. Epigenetics Stem Cell/Wnt
  3. Epigenetic Reader Domain Wnt
  4. EML631

EML631 是一种 SPIN1 抑制剂，Kd 为 3-7 μM。EML631 可与 SPIN1 的第二个 Tudor 结构域相互作用，阻断其读取 H3K4me3 组蛋白标记的能力。EML631 可抑制 Wnt 信号通路中 SPIN1 的共激活因子活性，降低 Wnt 应答报告基因的活性。EML631 可用于癌症的相关研究。

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EML631

EML631 Chemical Structure

CAS No. : 2101206-36-2

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EML631 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EML631 is a SPIN1 inhibitor with a Kd of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research[1][2].

体外研究
(In Vitro)

EML631 (15-30 mM) 像 SPIN-DOC，在 T778 细胞中阻断 SPIN1 的 H3K4me3 读取能力， 对 Wnt 信号通路活性具有相同的影响[1]。
EML631 可特异性结合 SPIN1 的 Tudor 结构域，经 ITC 测得其 Kd 为 3-7 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EML631 相关抗体:
分子量

684.97

Formula

C41H60N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EML631 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EML6312101206-36-2EML 631EML-631Epigenetic Reader DomainWntSpindlin1ovarian cancernonsmall cell lung cancersHEK293T cell lysatesWnt signaling pathwayH3K4me3 histone marksecond Tudor domainbreast cancerSPIN1liposarcomaInhibitorinhibitorinhibit

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