2. Metabolic Enzyme/Protease
  3. Elastase
  4. Endosidin1

Endosidin1 (Prieurianin) 是一种 A、B 环开裂型 Prieurianin。Endosidin1 可分离自 Aphanamixis polystachya 根部。Endosidin1 抑制中性粒细胞超氧阴离子生成及 Elastase 释放， IC50 >10 μg/mL。Endosidin1 在体外对喉癌细胞表现出轻度细胞毒活性。Endosidin1 展现抗炎活性。Endosidin1 可用于喉癌相关研究。


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Endosidin1

Endosidin1 Chemical Structure

CAS No. : 57672-91-0

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Endosidin1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC50 >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer[1].\n
体外研究
(In Vitro)

Endosidin1 (3 天) 对 HEp-2 喉癌细胞表现出轻度细胞毒性，其 ED50 为 16.77 μg/mL，而对 Hep-G2、A549 或 MCF-7 细胞无显著细胞毒性[1]。
Endosidin1 可使经 FMLP/CB 刺激的中性粒细胞的超氧阴离子生成量抑制 49.20%，其 IC50 >10 μg/mL[1]。
Endosidin1 (10 μg/mL) 可抑制经 FMLP/CB 刺激的中性粒细胞释放弹性蛋白酶，在 10 μg/mL 浓度下抑制率达 39.36%，其 IC50 >10 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Endosidin1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human HEp-2 (laryngeal carcinoma) cells, Hep-G2 cells, A549 cells, MCF-7 cells
Concentration: 16.77 μg/mL (HEp-2 ED50); >40 μg/mL (Hep-G2, A549, MCF-7 ED50)
Incubation Time: 3 days
Result: Showed mild cytotoxic activity against HEp-2 cells, with an IC50 value of 16.77 μg/mL.
Exhibited no significant cytotoxicity against Hep-G2, A549, or MCF-7 cells (ED50 >40 μg/mL for all three cell lines).
分子量

762.79

Formula

C38H50O16
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Endosidin1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endosidin157672-91-0PrieurianinEndosidin 1Endosidin-1ElastaseA549superoxide anion generationFMLP/CBhuman neutrophilsMCF-7human laryngeal carcinoma cellsHEp-2 laryngeal carcinoma cellsAphanamixis polystachyaelastase releaseHep-G2Inhibitorinhibitorinhibit

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