EPZ028862

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EPZ028862 是一种选择性的 SMYD3 抑制剂，可用于癌症研究。

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EPZ028862 Chemical Structure

CAS No. : 1887082-53-2

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查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

生物活性
纯度 & 产品资料
参考文献

生物活性

EPZ028862 is a selective SMYD3 inhibitor for cancer research^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
5637	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 5637 cells in 2D growth culture Antiproliferative activity against human 5637 cells in 2D growth culture	[PMID: 29856759]
5637	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 5637 cells in 3D growth culture Antiproliferative activity against human 5637 cells in 3D growth culture	[PMID: 29856759]
639-V	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 639-V cells in 2D growth culture Antiproliferative activity against human 639-V cells in 2D growth culture	[PMID: 29856759]
639-V	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 639-V cells in 3D growth culture Antiproliferative activity against human 639-V cells in 3D growth culture	[PMID: 29856759]
647-V	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 647-V cells in 2D growth culture Antiproliferative activity against human 647-V cells in 2D growth culture	[PMID: 29856759]
647-V	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 647-V cells in 3D growth culture Antiproliferative activity against human 647-V cells in 3D growth culture	[PMID: 29856759]
769-P	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 769-P cells in 2D growth culture Antiproliferative activity against human 769-P cells in 2D growth culture	[PMID: 29856759]
786-0	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 786-0 cells in 2D growth culture Antiproliferative activity against human 786-0 cells in 2D growth culture	[PMID: 29856759]
786-0	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 786-0 cells in 3D growth culture Antiproliferative activity against human 786-0 cells in 3D growth culture	[PMID: 29856759]
A 172	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-172 cells in 2D growth culture Antiproliferative activity against human A-172 cells in 2D growth culture	[PMID: 29856759]
A 172	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-172 cells in 3D growth culture Antiproliferative activity against human A-172 cells in 3D growth culture	[PMID: 29856759]
A-375	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-375 cells in 2D growth culture Antiproliferative activity against human A-375 cells in 2D growth culture	[PMID: 29856759]
A-427	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-427 cells in 2D growth culture Antiproliferative activity against human A-427 cells in 2D growth culture	[PMID: 29856759]
A-431	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-431 cells in 2D growth culture Antiproliferative activity against human A-431 cells in 2D growth culture	[PMID: 29856759]
A-431	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-431 cells in 3D growth culture Antiproliferative activity against human A-431 cells in 3D growth culture	[PMID: 29856759]
A101D	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A101D cells in 2D growth culture Antiproliferative activity against human A101D cells in 2D growth culture	[PMID: 29856759]
A101D	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A101D cells in 3D growth culture Antiproliferative activity against human A101D cells in 3D growth culture	[PMID: 29856759]
A204	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A204 cells in 2D growth culture Antiproliferative activity against human A204 cells in 2D growth culture	[PMID: 29856759]
A204	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A204 cells in 3D growth culture Antiproliferative activity against human A204 cells in 3D growth culture	[PMID: 29856759]
A498	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A-498 cells in 2D growth culture Antiproliferative activity against human A-498 cells in 2D growth culture	[PMID: 29856759]
A498	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A498 cells in 3D growth culture Antiproliferative activity against human A498 cells in 3D growth culture	[PMID: 29856759]
A549	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A549 cells expressing KRAS G12S mutant Antiproliferative activity against human A549 cells expressing KRAS G12S mutant	[PMID: 29856759]
A549	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A549 cells in 2D growth culture Antiproliferative activity against human A549 cells in 2D growth culture	[PMID: 29856759]
A549	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A549 cells in 3D growth culture Antiproliferative activity against human A549 cells in 3D growth culture	[PMID: 29856759]
A673	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A673 cells in 2D growth culture Antiproliferative activity against human A673 cells in 2D growth culture	[PMID: 29856759]
A673	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human A673 cells in 3D growth culture Antiproliferative activity against human A673 cells in 3D growth culture	[PMID: 29856759]
ACHN	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ACHN cells in 2D growth culture Antiproliferative activity against human ACHN cells in 2D growth culture	[PMID: 29856759]
ACHN	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ACHN cells in 3D growth culture Antiproliferative activity against human ACHN cells in 3D growth culture	[PMID: 29856759]
AGS	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human AGS cells in 2D growth culture Antiproliferative activity against human AGS cells in 2D growth culture	[PMID: 29856759]
AN3-CA	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human AN3-CA cells in 2D growth culture Antiproliferative activity against human AN3-CA cells in 2D growth culture	[PMID: 29856759]
AN3-CA	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human AN3-CA cells in 3D growth culture Antiproliferative activity against human AN3-CA cells in 3D growth culture	[PMID: 29856759]
ARH-77	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ARH-77 cells in 2D growth culture Antiproliferative activity against human ARH-77 cells in 2D growth culture	[PMID: 29856759]
ARH-77	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ARH-77 cells in 3D growth culture Antiproliferative activity against human ARH-77 cells in 3D growth culture	[PMID: 29856759]
ASPC1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ASPC1 cells in 2D growth culture Antiproliferative activity against human ASPC1 cells in 2D growth culture	[PMID: 29856759]
ASPC1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ASPC1 cells in 3D growth culture Antiproliferative activity against human ASPC1 cells in 3D growth culture	[PMID: 29856759]
AU565	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human AU565 cells in 2D growth culture Antiproliferative activity against human AU565 cells in 2D growth culture	[PMID: 29856759]
AU565	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human AU565 cells in 3D growth culture Antiproliferative activity against human AU565 cells in 3D growth culture	[PMID: 29856759]
BFTC-905	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BFTC-905 cells in 2D growth culture Antiproliferative activity against human BFTC-905 cells in 2D growth culture	[PMID: 29856759]
BFTC-905	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BFTC-905 cells in 3D growth culture Antiproliferative activity against human BFTC-905 cells in 3D growth culture	[PMID: 29856759]
BHT-101	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BHT-101 cells in 2D growth culture Antiproliferative activity against human BHT-101 cells in 2D growth culture	[PMID: 29856759]
BHT-101	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BHT-101 cells in 3D growth culture Antiproliferative activity against human BHT-101 cells in 3D growth culture	[PMID: 29856759]
BPH-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BPH-1 cells in 2D growth culture Antiproliferative activity against human BPH-1 cells in 2D growth culture	[PMID: 29856759]
BT-20	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BT-20 cells in 2D growth culture Antiproliferative activity against human BT-20 cells in 2D growth culture	[PMID: 29856759]
BT-20	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BT-20 cells in 3D growth culture Antiproliferative activity against human BT-20 cells in 3D growth culture	[PMID: 29856759]
BT-474	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BT-474 cells in 2D growth culture Antiproliferative activity against human BT-474 cells in 2D growth culture	[PMID: 29856759]
BT-474	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BT-474 cells in 3D growth culture Antiproliferative activity against human BT-474 cells in 3D growth culture	[PMID: 29856759]
BT-549	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BT-549 cells in 2D growth culture Antiproliferative activity against human BT-549 cells in 2D growth culture	[PMID: 29856759]
BV-173	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BV-173 cells in 2D growth culture Antiproliferative activity against human BV-173 cells in 2D growth culture	[PMID: 29856759]
BXPC-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BXPC-3 cells in 2D growth culture Antiproliferative activity against human BXPC-3 cells in 2D growth culture	[PMID: 29856759]
BXPC-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BXPC-3 cells in 3D growth culture Antiproliferative activity against human BXPC-3 cells in 3D growth culture	[PMID: 29856759]
BeWo	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BeWo cells in 2D growth culture Antiproliferative activity against human BeWo cells in 2D growth culture	[PMID: 29856759]
BeWo	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human BeWo cells in 3D growth culture Antiproliferative activity against human BeWo cells in 3D growth culture	[PMID: 29856759]
C-33-A	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human C-33-A cells in 2D growth culture Antiproliferative activity against human C-33-A cells in 2D growth culture	[PMID: 29856759]
C-4-II	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human C-4-II cells in 2D growth culture Antiproliferative activity against human C-4-II cells in 2D growth culture	[PMID: 29856759]
C-4-II	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human C-4-II cells in 3D growth culture Antiproliferative activity against human C-4-II cells in 3D growth culture	[PMID: 29856759]
C32	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human C32 cells in 2D growth culture Antiproliferative activity against human C32 cells in 2D growth culture	[PMID: 29856759]
C32	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human C32 cells in 3D growth culture Antiproliferative activity against human C32 cells in 3D growth culture	[PMID: 29856759]
CAKI-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAKI-1 cells in 2D growth culture Antiproliferative activity against human CAKI-1 cells in 2D growth culture	[PMID: 29856759]
CAKI-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAKI-1 cells in 3D growth culture Antiproliferative activity against human CAKI-1 cells in 3D growth culture	[PMID: 29856759]
CAKI-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAKI-2 cells in 2D growth culture Antiproliferative activity against human CAKI-2 cells in 2D growth culture	[PMID: 29856759]
CAL-27	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAL-27 cells in 2D growth culture Antiproliferative activity against human CAL-27 cells in 2D growth culture	[PMID: 29856759]
CAL-27	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAL-27 cells in 3D growth culture Antiproliferative activity against human CAL-27 cells in 3D growth culture	[PMID: 29856759]
CAL-62	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAL-62 cells in 2D growth culture Antiproliferative activity against human CAL-62 cells in 2D growth culture	[PMID: 29856759]
CAMA-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAMA-1 cells in 2D growth culture Antiproliferative activity against human CAMA-1 cells in 2D growth culture	[PMID: 29856759]
CAMA-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAMA-1 cells in 3D growth culture Antiproliferative activity against human CAMA-1 cells in 3D growth culture	[PMID: 29856759]
CAPAN-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CAPAN-1 cells in 2D growth culture Antiproliferative activity against human CAPAN-1 cells in 2D growth culture	[PMID: 29856759]
CCF-STTG1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CCF-STTG1 cells in 2D growth culture Antiproliferative activity against human CCF-STTG1 cells in 2D growth culture	[PMID: 29856759]
CCRF-CEM	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CCRF-CEM cells in 2D growth culture Antiproliferative activity against human CCRF-CEM cells in 2D growth culture	[PMID: 29856759]
CFPAC-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CFPAC-1 cells in 2D growth culture Antiproliferative activity against human CFPAC-1 cells in 2D growth culture	[PMID: 29856759]
CFPAC-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CFPAC-1 cells in 3D growth culture Antiproliferative activity against human CFPAC-1 cells in 3D growth culture	[PMID: 29856759]
CGTH-W-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CGTH-W-1 cells in 2D growth culture Antiproliferative activity against human CGTH-W-1 cells in 2D growth culture	[PMID: 29856759]
CGTH-W-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CGTH-W-1 cells in 3D growth culture Antiproliferative activity against human CGTH-W-1 cells in 3D growth culture	[PMID: 29856759]
CHL-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CHL-1 cells in 2D growth culture Antiproliferative activity against human CHL-1 cells in 2D growth culture	[PMID: 29856759]
CHL-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CHL-1 cells in 3D growth culture Antiproliferative activity against human CHL-1 cells in 3D growth culture	[PMID: 29856759]
CHP-212	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CHP-212 cells in 2D growth culture Antiproliferative activity against human CHP-212 cells in 2D growth culture	[PMID: 29856759]
COLO 201	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO201 cells in 2D growth culture Antiproliferative activity against human COLO201 cells in 2D growth culture	[PMID: 29856759]
COLO 201	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO201 cells in 3D growth culture Antiproliferative activity against human COLO201 cells in 3D growth culture	[PMID: 29856759]
COLO 205	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO 205 cells in 2D growth culture Antiproliferative activity against human COLO 205 cells in 2D growth culture	[PMID: 29856759]
COLO 205	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO 205 cells in 3D growth culture Antiproliferative activity against human COLO 205 cells in 3D growth culture	[PMID: 29856759]
COLO 320DM	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO320DM cells in 2D growth culture Antiproliferative activity against human COLO320DM cells in 2D growth culture	[PMID: 29856759]
COLO 320DM	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO320DM cells in 3D growth culture Antiproliferative activity against human COLO320DM cells in 3D growth culture	[PMID: 29856759]
COLO-320-HSR	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO 320HSR cells in 2D growth culture Antiproliferative activity against human COLO 320HSR cells in 2D growth culture	[PMID: 29856759]
COLO-320-HSR	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO320HSR cells in 3D growth culture Antiproliferative activity against human COLO320HSR cells in 3D growth culture	[PMID: 29856759]
COLO-829	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COLO-829 cells in 2D growth culture Antiproliferative activity against human COLO-829 cells in 2D growth culture	[PMID: 29856759]
COR-L105	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L105 cells expressing wild-type KRAS Antiproliferative activity against human COR-L105 cells expressing wild-type KRAS	[PMID: 29856759]
COR-L105	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L105 cells in 2D growth culture Antiproliferative activity against human COR-L105 cells in 2D growth culture	[PMID: 29856759]
COR-L105	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L105 cells in 3D growth culture Antiproliferative activity against human COR-L105 cells in 3D growth culture	[PMID: 29856759]
COR-L23	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L23 cells in 2D growth culture Antiproliferative activity against human COR-L23 cells in 2D growth culture	[PMID: 29856759]
COR-L23	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L23 cells in 3D growth culture Antiproliferative activity against human COR-L23 cells in 3D growth culture	[PMID: 29856759]
COR-L88	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human COR-L88 cells expressing wild-type KRAS Antiproliferative activity against human COR-L88 cells expressing wild-type KRAS	[PMID: 29856759]
CRO-AP2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human CRO-AP2 cells in 2D growth culture Antiproliferative activity against human CRO-AP2 cells in 2D growth culture	[PMID: 29856759]
CWR22R	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 22Rv1 cells in 2D growth culture Antiproliferative activity against human 22Rv1 cells in 2D growth culture	[PMID: 29856759]
CWR22R	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human 22Rv1 cells in 3D growth culture Antiproliferative activity against human 22Rv1 cells in 3D growth culture	[PMID: 29856759]
Calu-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Calu-1 cells in 2D growth culture Antiproliferative activity against human Calu-1 cells in 2D growth culture	[PMID: 29856759]
Calu-6	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Calu-6 cells in 2D growth culture Antiproliferative activity against human Calu-6 cells in 2D growth culture	[PMID: 29856759]
Capan-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Capan-2 cells in 2D growth culture Antiproliferative activity against human Capan-2 cells in 2D growth culture	[PMID: 29856759]
Capan-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Capan-2 cells in 3D growth culture Antiproliferative activity against human Capan-2 cells in 3D growth culture	[PMID: 29856759]
ChaGo-K-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ChaGo-K-1 cells in 2D growth culture Antiproliferative activity against human ChaGo-K-1 cells in 2D growth culture	[PMID: 29856759]
D283 Med	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human D283 Med cells in 2D growth culture Antiproliferative activity against human D283 Med cells in 2D growth culture	[PMID: 29856759]
D283 Med	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human D283 Med cells in 3D growth culture Antiproliferative activity against human D283 Med cells in 3D growth culture	[PMID: 29856759]
DB	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DB cells in 2D growth culture Antiproliferative activity against human DB cells in 2D growth culture	[PMID: 29856759]
DBTRG-05MG	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DBTRG-05MG cells in 2D growth culture Antiproliferative activity against human DBTRG-05MG cells in 2D growth culture	[PMID: 29856759]
DK-MG	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DK-MG cells in 2D growth culture Antiproliferative activity against human DK-MG cells in 2D growth culture	[PMID: 29856759]
DLD-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DLD-1 cells in 2D growth culture Antiproliferative activity against human DLD-1 cells in 2D growth culture	[PMID: 29856759]
DLD-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DLD-1 cells in 3D growth culture Antiproliferative activity against human DLD-1 cells in 3D growth culture	[PMID: 29856759]
DMS-114	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-114 cells in 2D growth culture Antiproliferative activity against human DMS-114 cells in 2D growth culture	[PMID: 29856759]
DMS-153	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-153 cells expressing wild-type KRAS Antiproliferative activity against human DMS-153 cells expressing wild-type KRAS	[PMID: 29856759]
DMS-273	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-273 cells in 2D growth culture Antiproliferative activity against human DMS-273 cells in 2D growth culture	[PMID: 29856759]
DMS-273	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-273 cells in 3D growth culture Antiproliferative activity against human DMS-273 cells in 3D growth culture	[PMID: 29856759]
DMS-53	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-53 expressing wild-type KRAS Antiproliferative activity against human DMS-53 expressing wild-type KRAS	[PMID: 29856759]
DMS-53	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-53 cells in 2D growth culture Antiproliferative activity against human DMS-53 cells in 2D growth culture	[PMID: 29856759]
DMS-53	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DMS-53 cells in 3D growth culture Antiproliferative activity against human DMS-53 cells in 3D growth culture	[PMID: 29856759]
DOHH-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DOHH-2 cells in 2D growth culture Antiproliferative activity against human DOHH-2 cells in 2D growth culture	[PMID: 29856759]
DU-145	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DU-145 cells in 2D growth culture Antiproliferative activity against human DU-145 cells in 2D growth culture	[PMID: 29856759]
DU-145	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DU-145 cells in 3D growth culture Antiproliferative activity against human DU-145 cells in 3D growth culture	[PMID: 29856759]
Daoy	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Daoy cells in 2D growth culture Antiproliferative activity against human Daoy cells in 2D growth culture	[PMID: 29856759]
Daudi	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Daudi cells in 2D growth culture Antiproliferative activity against human Daudi cells in 2D growth culture	[PMID: 29856759]
Detroit 562	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Detroit 562 cells in 2D growth culture Antiproliferative activity against human Detroit 562 cells in 2D growth culture	[PMID: 29856759]
Detroit 562	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Detroit 562 cells in 3D growth culture Antiproliferative activity against human Detroit 562 cells in 3D growth culture	[PMID: 29856759]
DoTc2-4510	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DoTc2-4510 cells in 2D growth culture Antiproliferative activity against human DoTc2-4510 cells in 2D growth culture	[PMID: 29856759]
DoTc2-4510	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human DoTc2-4510 cells in 3D growth culture Antiproliferative activity against human DoTc2-4510 cells in 3D growth culture	[PMID: 29856759]
EB-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human EB-3 cells in 2D growth culture Antiproliferative activity against human EB-3 cells in 2D growth culture	[PMID: 29856759]
EFM-19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human EFM-19 cells in 2D growth culture Antiproliferative activity against human EFM-19 cells in 2D growth culture	[PMID: 29856759]
EFM-19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human EFM-19 cells in 3D growth culture Antiproliferative activity against human EFM-19 cells in 3D growth culture	[PMID: 29856759]
EM-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human EM-2 cells in 2D growth culture Antiproliferative activity against human EM-2 cells in 2D growth culture	[PMID: 29856759]
ES-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ES-2 cells in 2D growth culture Antiproliferative activity against human ES-2 cells in 2D growth culture	[PMID: 29856759]
ES-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ES2 cells in 3D growth culture Antiproliferative activity against human ES2 cells in 3D growth culture	[PMID: 29856759]
FaDu	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human FaDu cells in 2D growth culture Antiproliferative activity against human FaDu cells in 2D growth culture	[PMID: 29856759]
FaDu	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human FaDu cells in 3D growth culture Antiproliferative activity against human FaDu cells in 3D growth culture	[PMID: 29856759]
G-401	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human G-401 cells in 2D growth culture Antiproliferative activity against human G-401 cells in 2D growth culture	[PMID: 29856759]
G-401	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human G-401 cells in 3D growth culture Antiproliferative activity against human G-401 cells in 3D growth culture	[PMID: 29856759]
G-402	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human G-402 cells in 2D growth culture Antiproliferative activity against human G-402 cells in 2D growth culture	[PMID: 29856759]
H4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human H4 cells in 2D growth culture Antiproliferative activity against human H4 cells in 2D growth culture	[PMID: 29856759]
HCT-116	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-116 cells in 2D growth culture Antiproliferative activity against human HCT-116 cells in 2D growth culture	[PMID: 29856759]
HCT-116	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-116 cells in 3D growth culture Antiproliferative activity against human HCT-116 cells in 3D growth culture	[PMID: 29856759]
HCT-15	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-15 cells in 2D growth culture Antiproliferative activity against human HCT-15 cells in 2D growth culture	[PMID: 29856759]
HCT-15	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-15 cells in 3D growth culture Antiproliferative activity against human HCT-15 cells in 3D growth culture	[PMID: 29856759]
HCT-8	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-8 cells in 2D growth culture Antiproliferative activity against human HCT-8 cells in 2D growth culture	[PMID: 29856759]
HCT-8	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HCT-8 cells in 3D growth culture Antiproliferative activity against human HCT-8 cells in 3D growth culture	[PMID: 29856759]
HEC-1-A	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HEC-1-A cells in 2D growth culture Antiproliferative activity against human HEC-1-A cells in 2D growth culture	[PMID: 29856759]
HEC-1-A	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HEC-1-A cells in 3D growth culture Antiproliferative activity against human HEC-1-A cells in 3D growth culture	[PMID: 29856759]
HEL 92.1.7	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HEL 92.1.7 cells in 2D growth culture Antiproliferative activity against human HEL 92.1.7 cells in 2D growth culture	[PMID: 29856759]
HLE	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HLE cells in 2D growth culture Antiproliferative activity against human HLE cells in 2D growth culture	[PMID: 29856759]
HOS	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HOS cells in 2D growth culture Antiproliferative activity against human HOS cells in 2D growth culture	[PMID: 29856759]
HPAF-II	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HPAF-II cells in 2D growth culture Antiproliferative activity against human HPAF-II cells in 2D growth culture	[PMID: 29856759]
HPAF-II	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HPAF-II cells in 3D growth culture Antiproliferative activity against human HPAF-II cells in 3D growth culture	[PMID: 29856759]
HT	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT cells in 2D growth culture Antiproliferative activity against human HT cells in 2D growth culture	[PMID: 29856759]
HT-1080	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-1080 cells in 2D growth culture Antiproliferative activity against human HT-1080 cells in 2D growth culture	[PMID: 29856759]
HT-1376	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-1376 cells in 2D growth culture Antiproliferative activity against human HT-1376 cells in 2D growth culture	[PMID: 29856759]
HT-1376	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-1376 cells in 3D growth culture Antiproliferative activity against human HT-1376 cells in 3D growth culture	[PMID: 29856759]
HT-29	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-29 cells in 2D growth culture Antiproliferative activity against human HT-29 cells in 2D growth culture	[PMID: 29856759]
HT-29	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-29 cells in 3D growth culture Antiproliferative activity against human HT-29 cells in 3D growth culture	[PMID: 29856759]
HT-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-3 cells in 2D growth culture Antiproliferative activity against human HT-3 cells in 2D growth culture	[PMID: 29856759]
HT-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT-3 cells in 3D growth culture Antiproliferative activity against human HT-3 cells in 3D growth culture	[PMID: 29856759]
HT1197	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT1197 cells in 2D growth culture Antiproliferative activity against human HT1197 cells in 2D growth culture	[PMID: 29856759]
HT1197	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HT1197 cells in 3D growth culture Antiproliferative activity against human HT1197 cells in 3D growth culture	[PMID: 29856759]
HUH-6-clone5	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HUH-6-clone5 cells in 2D growth culture Antiproliferative activity against human HUH-6-clone5 cells in 2D growth culture	[PMID: 29856759]
HUH-6-clone5	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HUH-6-clone5 cells in 3D growth culture Antiproliferative activity against human HUH-6-clone5 cells in 3D growth culture	[PMID: 29856759]
HeLa	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HeLa cells in 2D growth culture Antiproliferative activity against human HeLa cells in 2D growth culture	[PMID: 29856759]
HepG2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HepG2 cells in 2D growth culture Antiproliferative activity against human HepG2 cells in 2D growth culture	[PMID: 29856759]
HepG2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HepG2 cells in 3D growth culture Antiproliferative activity against human HepG2 cells in 3D growth culture	[PMID: 29856759]
HepG2	IC₅₀	> 40 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 29856759]
Hs 294T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs294T cells in 2D growth culture Antiproliferative activity against human Hs294T cells in 2D growth culture	[PMID: 29856759]
Hs 695T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs 695T cells in 2D growth culture Antiproliferative activity against human Hs 695T cells in 2D growth culture	[PMID: 29856759]
Hs 766	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs 766T cells in 2D growth culture Antiproliferative activity against human Hs 766T cells in 2D growth culture	[PMID: 29856759]
Hs 766	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs766T cells in 3D growth culture Antiproliferative activity against human Hs766T cells in 3D growth culture	[PMID: 29856759]
Hs-578T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs-578T cells in 2D growth culture Antiproliferative activity against human Hs-578T cells in 2D growth culture	[PMID: 29856759]
Hs746T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs746T cells in 2D growth culture Antiproliferative activity against human Hs746T cells in 2D growth culture	[PMID: 29856759]
Hs746T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Hs746T cells in 3D growth culture Antiproliferative activity against human Hs746T cells in 3D growth culture	[PMID: 29856759]
HuCCT-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HuCCT-1 cells in 2D growth culture Antiproliferative activity against human HuCCT-1 cells in 2D growth culture	[PMID: 29856759]
HuP-T4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HuP-T4 cells in 2D growth culture Antiproliferative activity against human HuP-T4 cells in 2D growth culture	[PMID: 29856759]
HuP-T4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human HuP-T4 cells in 3D growth culture Antiproliferative activity against human HuP-T4 cells in 3D growth culture	[PMID: 29856759]
J-RT3-T3-5	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human J-RT3-T3-5 cells in 2D growth culture Antiproliferative activity against human J-RT3-T3-5 cells in 2D growth culture	[PMID: 29856759]
J82	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human J82 cells in 2D growth culture Antiproliferative activity against human J82 cells in 2D growth culture	[PMID: 29856759]
J82	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human J82 cells in 3D growth culture Antiproliferative activity against human J82 cells in 3D growth culture	[PMID: 29856759]
JAR	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human JAR cells in 2D growth culture Antiproliferative activity against human JAR cells in 2D growth culture	[PMID: 29856759]
JAR	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human JAR cells in 3D growth culture Antiproliferative activity against human JAR cells in 3D growth culture	[PMID: 29856759]
JEG-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human JEG-3 cells in 2D growth culture Antiproliferative activity against human JEG-3 cells in 2D growth culture	[PMID: 29856759]
JEG-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human JEG-3 cells in 3D growth culture Antiproliferative activity against human JEG-3 cells in 3D growth culture	[PMID: 29856759]
Jurkat	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Jurkat cells in 2D growth culture Antiproliferative activity against human Jurkat cells in 2D growth culture	[PMID: 29856759]
K562	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human K562 cells in 2D growth culture Antiproliferative activity against human K562 cells in 2D growth culture	[PMID: 29856759]
K562	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human K562 cells in 3D growth culture Antiproliferative activity against human K562 cells in 3D growth culture	[PMID: 29856759]
KLE	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human KLE cells in 2D growth culture Antiproliferative activity against human KLE cells in 2D growth culture	[PMID: 29856759]
L-428	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human L-428 cells in 2D growth culture Antiproliferative activity against human L-428 cells in 2D growth culture	[PMID: 29856759]
LNCaP	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LNCaP cells in 2D growth culture Antiproliferative activity against human LNCaP cells in 2D growth culture	[PMID: 29856759]
LNCaP	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LNCaP cells in 3D growth culture Antiproliferative activity against human LNCaP cells in 3D growth culture	[PMID: 29856759]
LS-1034	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LS1034 cells in 2D growth culture Antiproliferative activity against human LS1034 cells in 2D growth culture	[PMID: 29856759]
LS-1034	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LS1034 cells in 3D growth culture Antiproliferative activity against human LS1034 cells in 3D growth culture	[PMID: 29856759]
LS174T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LS174T cells in 2D growth culture Antiproliferative activity against human LS174T cells in 2D growth culture	[PMID: 29856759]
LS174T	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human LS174T cells in 3D growth culture Antiproliferative activity against human LS174T cells in 3D growth culture	[PMID: 29856759]
MC-IXC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MC-IXC cells in 2D growth culture Antiproliferative activity against human MC-IXC cells in 2D growth culture	[PMID: 29856759]
MC-IXC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MC-IXC cells in 3D growth culture Antiproliferative activity against human MC-IXC cells in 3D growth culture	[PMID: 29856759]
MCF7	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MCF7 cells in 2D growth culture Antiproliferative activity against human MCF7 cells in 2D growth culture	[PMID: 29856759]
MCF7	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MCF7 cells in 3D growth culture Antiproliferative activity against human MCF7 cells in 3D growth culture	[PMID: 29856759]
MDA-MB-231	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-231 cells in 2D growth culture Antiproliferative activity against human MDA-MB-231 cells in 2D growth culture	[PMID: 29856759]
MDA-MB-436	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-436 cells in 2D growth culture Antiproliferative activity against human MDA-MB-436 cells in 2D growth culture	[PMID: 29856759]
MDA-MB-436	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-436 cells in 3D growth culture Antiproliferative activity against human MDA-MB-436 cells in 3D growth culture	[PMID: 29856759]
MDA-MB-453	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-453 cells in 2D growth culture Antiproliferative activity against human MDA-MB-453 cells in 2D growth culture	[PMID: 29856759]
MDA-MB-453	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-453 cells in 3D growth culture Antiproliferative activity against human MDA-MB-453 cells in 3D growth culture	[PMID: 29856759]
MDA-MB-468	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MDA-MB-468 cells in 2D growth culture Antiproliferative activity against human MDA-MB-468 cells in 2D growth culture	[PMID: 29856759]
MEG-01	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MEG-01 cells in 2D growth culture Antiproliferative activity against human MEG-01 cells in 2D growth culture	[PMID: 29856759]
MES-SA	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MES-SA cells in 2D growth culture Antiproliferative activity against human MES-SA cells in 2D growth culture	[PMID: 29856759]
MES-SA	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MES-SA cells in 3D growth culture Antiproliferative activity against human MES-SA cells in 3D growth culture	[PMID: 29856759]
MG-63	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MG-63 cells in 2D growth culture Antiproliferative activity against human MG-63 cells in 2D growth culture	[PMID: 29856759]
MHH-PREB-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MHH-PREB-1 cells in 2D growth culture Antiproliferative activity against human MHH-PREB-1 cells in 2D growth culture	[PMID: 29856759]
MIA PaCa-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MIA PaCa-2 cells in 2D growth culture Antiproliferative activity against human MIA PaCa-2 cells in 2D growth culture	[PMID: 29856759]
MOLT-16	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MOLT-16 cells in 2D growth culture Antiproliferative activity against human MOLT-16 cells in 2D growth culture	[PMID: 29856759]
MOLT-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MOLT-3 cells in 2D growth culture Antiproliferative activity against human MOLT-3 cells in 2D growth culture	[PMID: 29856759]
MV4-11	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MV4-11 cells in 2D growth culture Antiproliferative activity against human MV4-11 cells in 2D growth culture	[PMID: 29856759]
MX1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MX1 cells in 2D growth culture Antiproliferative activity against human MX1 cells in 2D growth culture	[PMID: 29856759]
Malme-3M	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Malme-3M cells in 2D growth culture Antiproliferative activity against human Malme-3M cells in 2D growth culture	[PMID: 29856759]
MeWo	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MeWo cells in 2D growth culture Antiproliferative activity against human MeWo cells in 2D growth culture	[PMID: 29856759]
MeWo	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human MeWo cells in 3D growth culture Antiproliferative activity against human MeWo cells in 3D growth culture	[PMID: 29856759]
NALM-6	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NALM-6 cells in 2D growth culture Antiproliferative activity against human NALM-6 cells in 2D growth culture	[PMID: 29856759]
NCI-H2029	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H2029 cells expressing wild-type KRAS Antiproliferative activity against human NCI-H2029 cells expressing wild-type KRAS	[PMID: 29856759]
NCI-H2081	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H2081 cells expressing wild-type KRAS Antiproliferative activity against human NCI-H2081 cells expressing wild-type KRAS	[PMID: 29856759]
NCI-H2122	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H2122 cells expressing KRAS G12C mutant Antiproliferative activity against human NCI-H2122 cells expressing KRAS G12C mutant	[PMID: 29856759]
NCI-H23	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H23 cells expressing KRAS G12C mutant Antiproliferative activity against human NCI-H23 cells expressing KRAS G12C mutant	[PMID: 29856759]
NCI-H292	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H292 cells in 2D growth culture Antiproliferative activity against human NCI-H292 cells in 2D growth culture	[PMID: 29856759]
NCI-H292	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H292 cells in 3D growth culture Antiproliferative activity against human NCI-H292 cells in 3D growth culture	[PMID: 29856759]
NCI-H295R	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H295R cells in 2D growth culture Antiproliferative activity against human NCI-H295R cells in 2D growth culture	[PMID: 29856759]
NCI-H441	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H441 cells expressing KRAS G12V mutant Antiproliferative activity against human NCI-H441 cells expressing KRAS G12V mutant	[PMID: 29856759]
NCI-H441	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H441 cells in 2D growth culture Antiproliferative activity against human NCI-H441 cells in 2D growth culture	[PMID: 29856759]
NCI-H441	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H441 cells in 3D growth culture Antiproliferative activity against human NCI-H441 cells in 3D growth culture	[PMID: 29856759]
NCI-H446	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H446 cells in 2D growth culture Antiproliferative activity against human NCI-H446 cells in 2D growth culture	[PMID: 29856759]
NCI-H446	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H446 cells in 3D growth culture Antiproliferative activity against human NCI-H446 cells in 3D growth culture	[PMID: 29856759]
NCI-H460	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H460 cells in 2D growth culture Antiproliferative activity against human NCI-H460 cells in 2D growth culture	[PMID: 29856759]
NCI-H460	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H460 cells in 3D growth culture Antiproliferative activity against human NCI-H460 cells in 3D growth culture	[PMID: 29856759]
NCI-H508	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H508 cells in 2D growth culture Antiproliferative activity against human NCI-H508 cells in 2D growth culture	[PMID: 29856759]
NCI-H508	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H508 cells in 3D growth culture Antiproliferative activity against human NCI-H508 cells in 3D growth culture	[PMID: 29856759]
NCI-H520	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H520 cells in 2D growth culture Antiproliferative activity against human NCI-H520 cells in 2D growth culture	[PMID: 29856759]
NCI-H520	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H520 cells in 3D growth culture Antiproliferative activity against human NCI-H520 cells in 3D growth culture	[PMID: 29856759]
NCI-H596	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H596 cells in 2D growth culture Antiproliferative activity against human NCI-H596 cells in 2D growth culture	[PMID: 29856759]
NCI-H596	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H596 cells in 3D growth culture Antiproliferative activity against human NCI-H596 cells in 3D growth culture	[PMID: 29856759]
NCI-H661	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H661 cells in 2D growth culture Antiproliferative activity against human NCI-H661 cells in 2D growth culture	[PMID: 29856759]
NCI-H69	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H69 cells in 2D growth culture Antiproliferative activity against human NCI-H69 cells in 2D growth culture	[PMID: 29856759]
NCI-H69	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H69 cells in 3D growth culture Antiproliferative activity against human NCI-H69 cells in 3D growth culture	[PMID: 29856759]
NCI-H747	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human NCI-H747 cells in 2D growth culture Antiproliferative activity against human NCI-H747 cells in 2D growth culture	[PMID: 29856759]
OE19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OE19 cells in 2D growth culture Antiproliferative activity against human OE19 cells in 2D growth culture	[PMID: 29856759]
OE19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OE19 cells in 3D growth culture Antiproliferative activity against human OE19 cells in 3D growth culture	[PMID: 29856759]
OE33	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OE33 cells in 2D growth culture Antiproliferative activity against human OE33 cells in 2D growth culture	[PMID: 29856759]
OE33	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OE33 cells in 3D growth culture Antiproliferative activity against human OE33 cells in 3D growth culture	[PMID: 29856759]
OVCAR-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OVCAR-3 cells in 2D growth culture Antiproliferative activity against human OVCAR-3 cells in 2D growth culture	[PMID: 29856759]
OVCAR-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human OVCAR-3 cells in 3D growth culture Antiproliferative activity against human OVCAR-3 cells in 3D growth culture	[PMID: 29856759]
PANC-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human PANC-1 cells in 2D growth culture Antiproliferative activity against human PANC-1 cells in 2D growth culture	[PMID: 29856759]
PANC-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human PANC-1 cells in 3D growth culture Antiproliferative activity against human PANC-1 cells in 3D growth culture	[PMID: 29856759]
PC-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human PC-3 cells in 2D growth culture Antiproliferative activity against human PC-3 cells in 2D growth culture	[PMID: 29856759]
PC-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human PC-3 cells in 3D growth culture Antiproliferative activity against human PC-3 cells in 3D growth culture	[PMID: 29856759]
RD	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RD cells in 2D growth culture Antiproliferative activity against human RD cells in 2D growth culture	[PMID: 29856759]
RD	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RD cells in 3D growth culture Antiproliferative activity against human RD cells in 3D growth culture	[PMID: 29856759]
RKO	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RKO cells in 2D growth culture Antiproliferative activity against human RKO cells in 2D growth culture	[PMID: 29856759]
RKO	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RKO cells in 3D growth culture Antiproliferative activity against human RKO cells in 3D growth culture	[PMID: 29856759]
RL95-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RL95-2 cells in 2D growth culture Antiproliferative activity against human RL95-2 cells in 2D growth culture	[PMID: 29856759]
RL95-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RL95-2 cells in 3D growth culture Antiproliferative activity against human RL95-2 cells in 3D growth culture	[PMID: 29856759]
RPMI-6666	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RPMI-6666 cells in 2D growth culture Antiproliferative activity against human RPMI-6666 cells in 2D growth culture	[PMID: 29856759]
RPMI-6666	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RPMI-6666 cells in 3D growth culture Antiproliferative activity against human RPMI-6666 cells in 3D growth culture	[PMID: 29856759]
RPMI-7951	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RPMI-7951 cells in 2D growth culture Antiproliferative activity against human RPMI-7951 cells in 2D growth culture	[PMID: 29856759]
RPMI-8226	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human RPMI-8226 cells in 2D growth culture Antiproliferative activity against human RPMI-8226 cells in 2D growth culture	[PMID: 29856759]
Raji	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Raji cells in 2D growth culture Antiproliferative activity against human Raji cells in 2D growth culture	[PMID: 29856759]
Ramos	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Ramos cells in 2D growth culture Antiproliferative activity against human Ramos cells in 2D growth culture	[PMID: 29856759]
SAOS-2	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SAOS-2 cells in 2D growth culture Antiproliferative activity against human SAOS-2 cells in 2D growth culture	[PMID: 29856759]
SCC-25	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCC-25 cells in 2D growth culture Antiproliferative activity against human SCC-25 cells in 2D growth culture	[PMID: 29856759]
SCC-25	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCC-25 cells in 3D growth culture Antiproliferative activity against human SCC-25 cells in 3D growth culture	[PMID: 29856759]
SCC-4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCC-4 cells in 2D growth culture Antiproliferative activity against human SCC-4 cells in 2D growth culture	[PMID: 29856759]
SCC-9	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCC-9 cells in 2D growth culture Antiproliferative activity against human SCC-9 cells in 2D growth culture	[PMID: 29856759]
SCaBER	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCaBER cells in 2D growth culture Antiproliferative activity against human SCaBER cells in 2D growth culture	[PMID: 29856759]
SCaBER	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SCaBER cells in 3D growth culture Antiproliferative activity against human SCaBER cells in 3D growth culture	[PMID: 29856759]
SH-4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SH-4 cells in 2D growth culture Antiproliferative activity against human SH-4 cells in 2D growth culture	[PMID: 29856759]
SH-4	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SH-4 cells in 3D growth culture Antiproliferative activity against human SH-4 cells in 3D growth culture	[PMID: 29856759]
SHP77	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SHP77 cells expressing KRAS G12V mutant Antiproliferative activity against human SHP77 cells expressing KRAS G12V mutant	[PMID: 29856759]
SHP77	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SHP77 cells in 2D growth culture Antiproliferative activity against human SHP77 cells in 2D growth culture	[PMID: 29856759]
SHP77	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SHP77 cells in 3D growth culture Antiproliferative activity against human SHP77 cells in 3D growth culture	[PMID: 29856759]
SJRH30	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SJRH30 cells in 2D growth culture Antiproliferative activity against human SJRH30 cells in 2D growth culture	[PMID: 29856759]
SJRH30	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SJRH30 cells in 3D growth culture Antiproliferative activity against human SJRH30 cells in 3D growth culture	[PMID: 29856759]
SJSA-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SJSA-1 cells in 2D growth culture Antiproliferative activity against human SJSA-1 cells in 2D growth culture	[PMID: 29856759]
SJSA-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SJSA-1 cells in 3D growth culture Antiproliferative activity against human SJSA-1 cells in 3D growth culture	[PMID: 29856759]
SK-BR-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-BR-3 cells in 2D growth culture Antiproliferative activity against human SK-BR-3 cells in 2D growth culture	[PMID: 29856759]
SK-BR-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-BR-3 cells in 3D growth culture Antiproliferative activity against human SK-BR-3 cells in 3D growth culture	[PMID: 29856759]
SK-LMS-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-LMS-1 cells in 2D growth culture Antiproliferative activity against human SK-LMS-1 cells in 2D growth culture	[PMID: 29856759]
SK-LMS-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-LMS-1 cells in 3D growth culture Antiproliferative activity against human SK-LMS-1 cells in 3D growth culture	[PMID: 29856759]
SK-LU-1	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-LU-1 cells expressing KRAS G12D mutant Antiproliferative activity against human SK-LU-1 cells expressing KRAS G12D mutant	[PMID: 29856759]
SK-MEL-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MEL-1 cells in 2D growth culture Antiproliferative activity against human SK-MEL-1 cells in 2D growth culture	[PMID: 29856759]
SK-MEL-28	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MEL-28 cells in 2D growth culture Antiproliferative activity against human SK-MEL-28 cells in 2D growth culture	[PMID: 29856759]
SK-MEL-28	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MEL-28 cells in 3D growth culture Antiproliferative activity against human SK-MEL-28 cells in 3D growth culture	[PMID: 29856759]
SK-MEL3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MEL3 cells in 2D growth culture Antiproliferative activity against human SK-MEL3 cells in 2D growth culture	[PMID: 29856759]
SK-MES-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MES-1 cells in 2D growth culture Antiproliferative activity against human SK-MES-1 cells in 2D growth culture	[PMID: 29856759]
SK-MES-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-MES-1 cells in 3D growth culture Antiproliferative activity against human SK-MES-1 cells in 3D growth culture	[PMID: 29856759]
SK-N-AS	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-AS cells in 2D growth culture Antiproliferative activity against human SK-N-AS cells in 2D growth culture	[PMID: 29856759]
SK-N-AS	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-AS cells in 3D growth culture Antiproliferative activity against human SK-N-AS cells in 3D growth culture	[PMID: 29856759]
SK-N-DZ	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-DZ cells in 2D growth culture Antiproliferative activity against human SK-N-DZ cells in 2D growth culture	[PMID: 29856759]
SK-N-DZ	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-DZ cells in 3D growth culture Antiproliferative activity against human SK-N-DZ cells in 3D growth culture	[PMID: 29856759]
SK-N-FI	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-FI cells in 2D growth culture Antiproliferative activity against human SK-N-FI cells in 2D growth culture	[PMID: 29856759]
SK-N-FI	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-N-FI cells in 3D growth culture Antiproliferative activity against human SK-N-FI cells in 3D growth culture	[PMID: 29856759]
SK-NEP-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-NEP-1 cells in 2D growth culture Antiproliferative activity against human SK-NEP-1 cells in 2D growth culture	[PMID: 29856759]
SK-NEP-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-NEP-1 cells in 3D growth culture Antiproliferative activity against human SK-NEP-1 cells in 3D growth culture	[PMID: 29856759]
SK-OV-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-OV-3 cells in 2D growth culture Antiproliferative activity against human SK-OV-3 cells in 2D growth culture	[PMID: 29856759]
SK-OV-3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-OV-3 cells in 3D growth culture Antiproliferative activity against human SK-OV-3 cells in 3D growth culture	[PMID: 29856759]
SK-UT-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SK-UT-1 cells in 2D growth culture Antiproliferative activity against human SK-UT-1 cells in 2D growth culture	[PMID: 29856759]
SNB-19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNB-19 cells in 2D growth culture Antiproliferative activity against human SNB-19 cells in 2D growth culture	[PMID: 29856759]
SNB-19	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNB-19 cells in 3D growth culture Antiproliferative activity against human SNB-19 cells in 3D growth culture	[PMID: 29856759]
SNU-16	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU-16 cells in 2D growth culture Antiproliferative activity against human SNU-16 cells in 2D growth culture	[PMID: 29856759]
SNU-16	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU-16 cells in 3D growth culture Antiproliferative activity against human SNU-16 cells in 3D growth culture	[PMID: 29856759]
SNU-423	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU-423 cells in 2D growth culture Antiproliferative activity against human SNU-423 cells in 2D growth culture	[PMID: 29856759]
SNU-5	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU-5 cells in 2D growth culture Antiproliferative activity against human SNU-5 cells in 2D growth culture	[PMID: 29856759]
SNU-5	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU-5 cells in 3D growth culture Antiproliferative activity against human SNU-5 cells in 3D growth culture	[PMID: 29856759]
SNU1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU1 cells in 2D growth culture Antiproliferative activity against human SNU1 cells in 2D growth culture	[PMID: 29856759]
SNU1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SNU1 cells in 3D growth culture Antiproliferative activity against human SNU1 cells in 3D growth culture	[PMID: 29856759]
SR	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SR cells in 2D growth culture Antiproliferative activity against human SR cells in 2D growth culture	[PMID: 29856759]
ST486	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human ST486 cells in 2D growth culture Antiproliferative activity against human ST486 cells in 2D growth culture	[PMID: 29856759]
SU.86.86	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SU-86-86 cells in 2D growth culture Antiproliferative activity against human SU-86-86 cells in 2D growth culture	[PMID: 29856759]
SU.86.86	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SU-86-86 cells in 3D growth culture Antiproliferative activity against human SU-86-86 cells in 3D growth culture	[PMID: 29856759]
SW 954	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW 954 cells in 2D growth culture Antiproliferative activity against human SW 954 cells in 2D growth culture	[PMID: 29856759]
SW 962	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW 962 cells in 2D growth culture Antiproliferative activity against human SW 962 cells in 2D growth culture	[PMID: 29856759]
SW 962	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW 962 cells in 3D growth culture Antiproliferative activity against human SW 962 cells in 3D growth culture	[PMID: 29856759]
SW-620	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW620 cells in 2D growth culture Antiproliferative activity against human SW620 cells in 2D growth culture	[PMID: 29856759]
SW1088	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1088 cells in 2D growth culture Antiproliferative activity against human SW1088 cells in 2D growth culture	[PMID: 29856759]
SW1088	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1088 cells in 3D growth culture Antiproliferative activity against human SW1088 cells in 3D growth culture	[PMID: 29856759]
SW13	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW13 cells in 2D growth culture Antiproliferative activity against human SW13 cells in 2D growth culture	[PMID: 29856759]
SW1353	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1353 cells in 2D growth culture Antiproliferative activity against human SW1353 cells in 2D growth culture	[PMID: 29856759]
SW1417	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1417 cells in 2D growth culture Antiproliferative activity against human SW1417 cells in 2D growth culture	[PMID: 29856759]
SW1417	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1417 cells in 3D growth culture Antiproliferative activity against human SW1417 cells in 3D growth culture	[PMID: 29856759]
SW1463	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1463 cells in 2D growth culture Antiproliferative activity against human SW1463 cells in 2D growth culture	[PMID: 29856759]
SW1463	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1463 cells in 3D growth culture Antiproliferative activity against human SW1463 cells in 3D growth culture	[PMID: 29856759]
SW1573	IC₅₀	> 20 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1573 cells expressing KRAS G12C mutant Antiproliferative activity against human SW1573 cells expressing KRAS G12C mutant	[PMID: 29856759]
SW1783	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1783 cells in 2D growth culture Antiproliferative activity against human SW1783 cells in 2D growth culture	[PMID: 29856759]
SW1783	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW1783 cells in 3D growth culture Antiproliferative activity against human SW1783 cells in 3D growth culture	[PMID: 29856759]
SW48	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW48 cells in 2D growth culture Antiproliferative activity against human SW48 cells in 2D growth culture	[PMID: 29856759]
SW48	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW48 cells in 3D growth culture Antiproliferative activity against human SW48 cells in 3D growth culture	[PMID: 29856759]
SW480	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW480 cells in 2D growth culture Antiproliferative activity against human SW480 cells in 2D growth culture	[PMID: 29856759]
SW684	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW684 cells in 2D growth culture Antiproliferative activity against human SW684 cells in 2D growth culture	[PMID: 29856759]
SW684	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW684 cells in 3D growth culture Antiproliferative activity against human SW684 cells in 3D growth culture	[PMID: 29856759]
SW837	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW837 cells in 2D growth culture Antiproliferative activity against human SW837 cells in 2D growth culture	[PMID: 29856759]
SW837	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW837 cells in 3D growth culture Antiproliferative activity against human SW837 cells in 3D growth culture	[PMID: 29856759]
SW872	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW872 cells in 2D growth culture Antiproliferative activity against human SW872 cells in 2D growth culture	[PMID: 29856759]
SW872	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW872 cells in 3D growth culture Antiproliferative activity against human SW872 cells in 3D growth culture	[PMID: 29856759]
SW900	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW900 cells in 2D growth culture Antiproliferative activity against human SW900 cells in 2D growth culture	[PMID: 29856759]
SW900	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW900 cells in 3D growth culture Antiproliferative activity against human SW900 cells in 3D growth culture	[PMID: 29856759]
SW948	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW948 cells in 2D growth culture Antiproliferative activity against human SW948 cells in 2D growth culture	[PMID: 29856759]
SW948	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW948 cells in 3D growth culture Antiproliferative activity against human SW948 cells in 3D growth culture	[PMID: 29856759]
SW982	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SW982 cells in 2D growth culture Antiproliferative activity against human SW982 cells in 2D growth culture	[PMID: 29856759]
SiHa	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SiHa cells in 2D growth culture Antiproliferative activity against human SiHa cells in 2D growth culture	[PMID: 29856759]
SiHa	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human SiHa cells in 3D growth culture Antiproliferative activity against human SiHa cells in 3D growth culture	[PMID: 29856759]
T-24	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human T24 cells in 2D growth culture Antiproliferative activity against human T24 cells in 2D growth culture	[PMID: 29856759]
T47D	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human T47D cells in 2D growth culture Antiproliferative activity against human T47D cells in 2D growth culture	[PMID: 29856759]
T47D	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human T47D cells in 3D growth culture Antiproliferative activity against human T47D cells in 3D growth culture	[PMID: 29856759]
T98G	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human T98G cells in 2D growth culture Antiproliferative activity against human T98G cells in 2D growth culture	[PMID: 29856759]
T98G	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human T98G cells in 3D growth culture Antiproliferative activity against human T98G cells in 3D growth culture	[PMID: 29856759]
TCC-SUP	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human TCC-SUP cells in 2D growth culture Antiproliferative activity against human TCC-SUP cells in 2D growth culture	[PMID: 29856759]
THP-1	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human THP-1 cells in 2D growth culture Antiproliferative activity against human THP-1 cells in 2D growth culture	[PMID: 29856759]
U-266	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human U266B1 cells in 2D growth culture Antiproliferative activity against human U266B1 cells in 2D growth culture	[PMID: 29856759]
U-87MG ATCC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human U-87 MG cells in 3D growth culture Antiproliferative activity against human U-87 MG cells in 3D growth culture	[PMID: 29856759]
U-87MG ATCC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human U-87MG cells in 2D growth culture Antiproliferative activity against human U-87MG cells in 2D growth culture	[PMID: 29856759]
U138-MG	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human U138-MG cells in 2D growth culture Antiproliferative activity against human U138-MG cells in 2D growth culture	[PMID: 29856759]
U2OS	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human U2OS cells in 2D growth culture Antiproliferative activity against human U2OS cells in 2D growth culture	[PMID: 29856759]
UMUC3	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human UM-UC-3 cells in 2D growth culture Antiproliferative activity against human UM-UC-3 cells in 2D growth culture	[PMID: 29856759]
WiDr	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human WiDr cells in 2D growth culture Antiproliferative activity against human WiDr cells in 2D growth culture	[PMID: 29856759]
WiDr	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human WiDr cells in 3D growth culture Antiproliferative activity against human WiDr cells in 3D growth culture	[PMID: 29856759]
Y79	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Y79 cells in 2D growth culture Antiproliferative activity against human Y79 cells in 2D growth culture	[PMID: 29856759]
Y79	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human Y79 cells in 3D growth culture Antiproliferative activity against human Y79 cells in 3D growth culture	[PMID: 29856759]
YAPC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human YAPC cells in 2D growth culture Antiproliferative activity against human YAPC cells in 2D growth culture	[PMID: 29856759]
YAPC	IC₅₀	> 25 μM Compound: Chemical probe: EPZ028862	Antiproliferative activity against human YAPC cells in 3D growth culture Antiproliferative activity against human YAPC cells in 3D growth culture	[PMID: 29856759]

体内研究
(In Vivo)

The pharmacokinetic parameters of EPZ028862( IV: 1 mg/kg; PO: 5 mg/kg)

Parameter	Mouse	Rat	Dog	Cynomolgus
CLp(mL/min/kg)	79.8	32.7	13.9	21.4
CLr(mL/min/kg)	23.6	21	1.97	1.06
V_ss(L/kg)	9.5	4.4	5.8	9.5
t_1/2(h)	2	2.1	5.4	5.6
MRT(h)	2	59	7	7.4
t_max(h)	0.33	1	1.5	2
F(%)	100	59	70	62

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

422.54

Formula

C₂₀H₃₀N₄O₄S

CAS 号

1887082-53-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Michael J Thomenius, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372. [Content Brief]

EPZ028862 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ0288621887082-53-2EPZ 028862EPZ-028862Histone MethyltransferaseSMYD3cancerInhibitorinhibitorinhibit

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