2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. ER-67880

ER-67880 是一种强效的微管 (microtubule) 抑制剂，其 IC50 为 9.5 μM。ER-67880 对 KB、Colon 38 和 P338 细胞具有抗增殖作用，其 IC50 值分别为 0.55、0.2 和 0.76 μg/mL。ER-67880 会导致 G2/M 期停滞，并伴有异常的 DNA 复制。ER-67880 会下调 G1 期相关基因的表达。ER-67880 可用于多种癌症研究，包括鼻咽癌和小鼠腺癌的研究。

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ER-67880

ER-67880 Chemical Structure

CAS No. : 247186-96-5

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ER-67880 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1][2].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.37 μM
Compound: 5
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
[PMID: 12383017]
HCT-116 IC50
2.2 μM
Compound: 5
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
[PMID: 12383017]
KB IC50
0.55 μg/mL
Compound: 16
Antiproliferative activity against KB human nasopharynx carcinoma in vitro
Antiproliferative activity against KB human nasopharynx carcinoma in vitro
[PMID: 10508428]
KB IC50
0.55 μg/mL
Compound: 3
In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
[PMID: 10866386]
MC-38 IC50
0.2 μg/mL
Compound: 16
In vitro antiproliferative activity against colon 38 murine adenocarcinoma
In vitro antiproliferative activity against colon 38 murine adenocarcinoma
[PMID: 10508428]
MC-38 IC50
0.2 μg/mL
Compound: 3
In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
[PMID: 10866386]
P388 IC50
0.76 μg/mL
Compound: 16
Antiproliferative activity against P388 murine leukemia in vitro
Antiproliferative activity against P388 murine leukemia in vitro
[PMID: 10508428]
P388 IC50
0.76 μg/mL
Compound: 3
In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
[PMID: 10866386]
P388 IC50
1.2 μM
Compound: 5
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
[PMID: 12383017]
P388 IC50
1.2 μM
Compound: 5
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
[PMID: 12383017]
分子量

336.79

Formula

C15H13ClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ER-67880 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER-67880247186-96-5ER67880ER 67880Microtubule/TubulinKBColon 38P338 cellsG2/M phase arrestdehydrogenaseInhibitorinhibitorinhibit

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