2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Erbicin

Erbicin 是一种抗人 ErbB2 受体的单链抗体。Erbicin 能特异性结合 ErbB2 阳性细胞，抑制受体自身磷酸化，并被靶细胞内吞。Erbicin 可用于乳腺癌的相关研究。

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Erbicin

Erbicin Chemical Structure

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Erbicin 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Erbicin is a single-chain antibody against the human ErbB2 receptor. Erbicin specifically binds to ErbB2-positive cells, inhibits receptor autophosphorylation, and is internalized by target cells. Erbicin can be used in breast cancer-related research[1][2].

反应种属

Human
体外研究
(In Vitro)

Erbicin (50-500 nM; 2 h) 可与可溶性 ErbB2-ECD 结合，ELISA 测的 Kd 为 50 nM，与 ErbB2 阳性细胞结合，ELISA 测的 Kd 为 5 nM[1] 。
Erbicin (5-700 nM; 200 s association, 300 s dissociation) 可与可溶性 ErbB2-ECD 结合，通过 SPR 动力学分析测得其 Kd 为 46.7 nM[1]。
Erbicin (~3 μM; 400 s intervals) 可在溶液中结合可溶性 ErbB2-ECD，通过 ITC 测得其 Kd 为 77 nM，结合化学计量比为 1:1[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Erbicin 相关抗体:
基因 ID

2064  [NCBI]

Accession
靶点

ERBB2/HER2/CD340
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Erbicin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ErbicinEGFREpidermal growth factor receptorErbB-1HER1single-chain antibodyhuman ErbB2 receptor
Inhibitorinhibitorinhibit

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目录号：
HY-P991979
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