2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Eucatropine hydrochloride

Eucatropine hydrochloride 是一种有效的毒蕈碱型乙酰胆碱受体 (mAChR) 抑制剂，IC50 值为 0.583 μM。Eucatropine hydrochloride 是一种抗胆碱能剂。Eucatropine hydrochloride 通过猫的中枢胆碱能感受点产生行为效应。

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Eucatropine hydrochloride

Eucatropine hydrochloride Chemical Structure

CAS No. : 536-93-6

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Other Forms of Eucatropine hydrochloride:

Eucatropine hydrochloride 相关抗体

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

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  • 参考文献

生物活性

Eucatropine hydrochloride is a potent muscarinic acetylcholine receptor (mAChR) inhibitor with an IC50 value of 0.583 μM. Eucatropine hydrochloride acts as an anticholinergic agent. Eucatropine hydrochloride produces behavioral effects via central cholinergic receptive sites in cats[1][2].

体内研究
(In Vivo)

Eucatropine hydrochloride (0.2-2.0 mg；侧脑室注射) 可在未麻醉猫中引发轻微、持续时间短且不稳定的情绪变化，同时会产生持续性散瞳和呼吸急促、持续性共济失调，不会出现强迫性活动，且争斗行为几乎无法检测到[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female (2-4 kg; intracerebroventricular cannula implantation)[1]
Dosage: 0.2 mg, 0.5 mg, 1.0 mg, 2.0 mg
Administration: i.c.v.; single injection
Result: Produced inconsistent emotional effects including miaowing, loud calling, loss of interest of the surroundings, rage, threat, attack, defense, fighting with paws, and flight; no restlessness, impelling locomotion, vacant staring, or apprehension.
Caused consistent mydriasis and tachypnea; inconsistent dyspnea, licking, vomiting, salivation, defecation, and micturition.
Induced consistent ataxia; no scratching, rigidity, weakness with adynamia, myoclonic jerks, or convulsions.
Showed no measurable impelling locomotion at any tested dose.
Caused very short-duration, non-dose-dependent aggressive fighting behavior with mean duration near 0 minutes across all tested doses.
分子量

327.85

Formula

C17H26ClNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eucatropine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eucatropine536-93-6mAChRMuscarinic acetylcholine receptorcentral cholinoreceptor modulatorataxiamydriasischolinergic agentcentral cholinoreceptive sitespsychomotor stimulantunanesthetized catstachypneaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-117284A
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